{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T13:58:24Z","timestamp":1788357504958,"version":"build-2803163510"},"reference-count":44,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["intramural"],"award-info":[{"award-number":["intramural"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:p>Small intestinal neuroendocrine tumors are of putative enterochromaffin (EC) cell origin and are the most common malignancy in the small intestine. However, the tumorigenesis of these specified tumor types remains poorly understood. The present organoid studies show that the addition of TNF-\u03b1 to the microenvironment maintains the specificity of EC cells during their transformation to neuroendocrine tumors while blocking their dedifferentiation to ISC-derived adenomas.<\/jats:p>","DOI":"10.1152\/ajpgi.00407.2025","type":"journal-article","created":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T17:00:47Z","timestamp":1774717247000},"page":"G581-G590","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["TNF-\u03b1 alters dedifferentiation of enterochromaffin cells, redirecting toward neuroendocrine tumors"],"prefix":"10.1152","volume":"330","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3073-5126","authenticated-orcid":false,"given":"Yoshitatsu","family":"Sei","sequence":"first","affiliation":[{"name":", National Institutes of Health","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianying","family":"Feng","sequence":"additional","affiliation":[{"name":", National Institutes of Health","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xilin","family":"Zhao","sequence":"additional","affiliation":[{"name":", National Institutes of Health","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9608-547X","authenticated-orcid":false,"given":"Stephen A.","family":"Wank","sequence":"additional","affiliation":[{"name":", National Institutes of Health","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.116500"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2011.02537.x"},{"key":"B3","doi-asserted-by":"crossref","DOI":"10.1007\/BF00249330","volume":"222","author":"Lembeck F","year":"1954","journal-title":"Naunyn Schmiedebergs Arch Exp Pathol Pharmakol"},{"key":"B4","first-page":"181","volume":"31","author":"Lechago J","year":"1990","journal-title":"Monogr Pathol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1159\/000343232"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870715)60:2<201::aid-cncr2820600214>3.0.co;2-2"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19920901)70:5<1081::aid-cncr2820700512>3.0.co;2-9"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.03.007"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1177\/17588359231156871"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20834"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2821"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-17-0196"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.04.008"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izz016"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.0150"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1023\/a:1008988215904"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20172"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.06.051"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.02.226"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-19-0505"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/315115a0"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00205.2022"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00036.2018"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00278.2020"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)03339-X"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199710093371502"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/nature01764"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/ng747"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.12.005"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2018.04.048"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/nature07935"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/nature06196"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00278.2010"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2021.10.010"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v29.i21.3222"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2014.112"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/nature12599"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/nature09637"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/nature07416"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.106623"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/ng.175"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.1998.275.2.L311"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072132"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0914"}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpgi.00407.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T16:46:09Z","timestamp":1780505169000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpgi.00407.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,1]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5,1]]}},"alternative-id":["10.1152\/ajpgi.00407.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.00407.2025","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,1]]},"assertion":[{"value":"2025-11-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-02","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}