{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:00:24Z","timestamp":1770822024833,"version":"3.50.1"},"reference-count":32,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p>This study determined whether Heligmosomoides polygyrus induces intestinal regulatory T cells. Splenic T cells proliferate strongly when cultured with anti-CD3 and antigen-presenting cells (APC). Lamina propria T cells from mice with H. polygyrus mixed with normal splenic T cells from uninfected mice inhibited proliferation over 90%. Lamina propria T cells from mice without H. polygyrus only modestly affected T cell proliferation. The worm-induced regulatory T cell was CD8<jats:sup>+<\/jats:sup>and required splenic T cell contact to inhibit proliferation. The regulation also was IL-10 independent, but TAP-dependent, suggesting that it requires major histocompatibility complex (MHC) class I interaction. Additional studies employed mice with transgenic T cells that did not express functional TGF-\u03b2 receptors. The lamina propria T regulator inhibited proliferation of these transgenic T cells nearly 100%, suggesting that TGF-\u03b2 signaling via the T cell was not required. CD8<jats:sup>+<\/jats:sup>T cells were needed for worms to reverse piroxicam-induced colitis in Rag mice (T and B cell deficient) reconstituted with IL-10<jats:sup>\u2212\/\u2212<\/jats:sup>T cells. Thus H. polygyrus induces a regulatory CD8<jats:sup>+<\/jats:sup>lamina propria T cell that inhibits T cell proliferation and that appears to have a role in control of colitis.<\/jats:p>","DOI":"10.1152\/ajpgi.00409.2005","type":"journal-article","created":{"date-parts":[[2006,7,6]],"date-time":"2006-07-06T20:56:51Z","timestamp":1152219411000},"page":"G253-G259","source":"Crossref","is-referenced-by-count":80,"title":["Induction of CD8<sup>+<\/sup>regulatory T cells in the intestine by<i>Heligmosomoides polygyrus<\/i>infection"],"prefix":"10.1152","volume":"291","author":[{"given":"Ahmed","family":"Metwali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tommy","family":"Setiawan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur M.","family":"Blum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Urban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E.","family":"Elliott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long","family":"Hang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel V.","family":"Weinstock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.6.3284"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1996.d01-612.x"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00527.2003"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10182"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.079129"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00049.2002"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200324833"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1096\/fj.99-0885hyp"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2004.01.004"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.5.2508"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(95)80079-4"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1126\/science.256.5060.1213"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.12.6323"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.11.5931-5937.2002"},{"key":"R15","doi-asserted-by":"crossref","unstructured":"Kullberg MC, Pearce EJ, Hieny SE, Sher A, and Berzofsky JA.Infection with Schistosoma mansoni alters Th1\/Th2 cytokine responses to a non-parasite antigen.J Immunol148: 3264\u20133270, 1992.","DOI":"10.4049\/jimmunol.148.10.3264"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.10.5012"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(93)90119-Z"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(02)02288-3"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.19.1.683"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.8.3939"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.2.834"},{"key":"R22","doi-asserted-by":"crossref","unstructured":"Noble A, Zhao ZS, and Cantor H.Suppression of immune responses by CD8 cells. 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