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Eight healthy volunteers were intubated with an oroileal multilumen tube for continuous duodenal perfusion of essential amino acids (450 \u03bcmol\/min), ileal perfusion of graded doses of lipids (0, 50 and 100 mg\/min, each dose for 90\u2013120 min), aspiration of duodenal and ileal chyme, and intestinal manometry. Venous blood samples were obtained for measurement of GLP-1 and PYY. Ileal lipid perfusion dose dependently decreased endogenously stimulated trypsin [262 \u00b1 59 vs. 154 \u00b1 42 vs. 92 \u00b1 20 U\/min ( P &lt; 0.05)] and bile acid output [18.6 \u00b1 1.9 vs. 8.4 \u00b1 2.8 vs. 3.0 \u00b1 1.0 \u03bcmol\/min ( P &lt; 0.05)]. Duodenal motor activity was not inhibited by either lipid dose. Trypsin and bile acid output correlated inversely with the release of GLP-1 and PYY (absolute value of R &gt; 0.84; P &lt; 0.05), whereas the motility index did not. Physiological postprandial ileal lipid concentrations dose dependently inhibited human digestive pancreatic protease and bile acid output, but not intestinal motor activity. Thus physiological postprandial ileal nutrient exposure may be of importance for the termination of digestive secretory responses. Ileocolonic release of GLP-1 and PYY appears to participate in mediating these effects.<\/jats:p>","DOI":"10.1152\/ajpgi.00411.2005","type":"journal-article","created":{"date-parts":[[2005,12,2]],"date-time":"2005-12-02T01:24:59Z","timestamp":1133486699000},"page":"G704-G709","source":"Crossref","is-referenced-by-count":28,"title":["Inhibition of human pancreatic and biliary output but not intestinal motility by physiological intraileal lipid loads"],"prefix":"10.1152","volume":"290","author":[{"given":"Jutta","family":"Keller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Juul","family":"Holst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Layer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90227-C"},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Arndorfer RC, Stef JJ, Dodds WJ, Linehan JH, and Hogan WJ.Improved infusion system for intraluminal esophageal manometry.Gastroenterology73: 23\u201327, 1977.","DOI":"10.1016\/S0016-5085(19)32264-4"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1992.tb01453.x"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1172\/JCI103549"},{"key":"R5","unstructured":"Box GEP, Hunter WG, and Hunter JS.Statistics for Experimenters: An Introduction to Design, Data Analysis, and Model Building. 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