{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T06:39:24Z","timestamp":1781851164549,"version":"3.54.5"},"reference-count":24,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:p> Several investigators have observed that repeated acid infusions induce stronger symptoms (symptom hypersensitivity). The goal of our study was to determine whether symptom hypersensitivity is associated with esophageal contractile hypersensitivity. Subjects with chronic heartburn symptoms underwent simultaneous pressure and ultrasound imaging of esophagus. Normal saline and 0.1 N HCl were sequentially infused into the esophagus, and subjects scored heartburn symptoms on a 1\u201310 scale. Saline and HCl infusions were repeated in 10 subjects with a positive Bernstein test. Esophageal contraction amplitude and duration and muscularis propria thickness were measured using a computerized method during recording. Acid infusion induced heartburn. Esophageal contractions had higher amplitudes (pressure 114.2 \u00b1 7.0%) and longer duration (116.8 \u00b1 4.4%) during acid infusion compared with saline infusion. Average muscle thickness was greater during acid infusion than saline infusion (107.0 \u00b1 2.0%). Sustained esophageal contractions (SECs) were identified during acid infusion. A second acid infusion (acid-2) induced heartburn with shorter latency (93.0 \u00b1 15.0 vs. 317.0 \u00b1 43.0 s) and stronger severity (8.5 \u00b1 0.5 vs. 5.3 \u00b1 0.8) than the first acid infusion (acid-1). Contraction amplitudes (140.2 \u00b1 13.0%), average muscle thickness (118.0 \u00b1 3.3%), and contraction duration (148.5 \u00b1 5.6 vs. 116.8 \u00b1 4.4%) were higher during acid-2 than acid-1. Also, numbers of SECs were greater during acid-2 than acid-1 (31 in 8 subjects vs. 11 in 6 subjects). Our data show that acid infusion into esophagus induces esophageal hypersensitivity and that a close temporal correlation exists between symptom hypersensitivity and contractility hypersensitivity. <\/jats:p>","DOI":"10.1152\/ajpgi.00420.2003","type":"journal-article","created":{"date-parts":[[2004,2,25]],"date-time":"2004-02-25T02:27:55Z","timestamp":1077676075000},"page":"G65-G71","source":"Crossref","is-referenced-by-count":33,"title":["Symptom hypersensitivity to acid infusion is associated with hypersensitivity of esophageal contractility"],"prefix":"10.1152","volume":"287","author":[{"given":"Vikas","family":"Bhalla","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, University of California, San Diego 92161; and San Diego Veterans Affairs Medical Center, San Diego, California 92161"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmin","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, University of California, San Diego 92161; and San Diego Veterans Affairs Medical Center, San Diego, California 92161"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Puckett","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, University of California, San Diego 92161; and San Diego Veterans Affairs Medical Center, San Diego, California 92161"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravinder K.","family":"Mittal","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, University of California, San Diego 92161; and San Diego Veterans Affairs Medical Center, San Diego, California 92161"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02233010"},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Bernstein L and Baker L. 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