{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:17:22Z","timestamp":1789755442601,"version":"4.0.1"},"reference-count":33,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2017,11,1]]},"abstract":"<jats:p>Excessive or persistent inflammation and hepatocyte death are the key triggers of liver diseases. The poly(ADP-ribose) polymerase (PARP) proteins induce cell death and inflammation. Chemical inhibition of PARP activity protects against liver injury during concanavalin A (ConA)-induced hepatitis. In this mice model, ConA activates immune cells, which promote inflammation and induce hepatocyte death, mediated by the activated invariant natural killer T (iNKT) lymphocyte population. We analyzed immune cell populations in the liver and several lymphoid organs, such as the spleen, thymus, and bone marrow in Parp2-deficient mice to better define the role of PARP proteins in liver immunity and inflammation at steady state and during ConA-induced hepatitis. We show that 1) the genetic inactivation of Parp2, but not Parp1, protected mice from ConA hepatitis without deregulating cytokine expression and leucocyte recruitment; 2) cellularity was lower in the thymus, but not in spleen, liver, or bone marrow of Parp2<jats:sup>\u2212\/\u2212<\/jats:sup>mice; 3) spleen and liver iNKT lymphocytes, as well as thymic T and NKT lymphocytes were reduced in Parp2 knockout mice. In conclusion, our results suggest that the defect of T-lymphocyte maturation in Parp2 knockout mice leads to a systemic reduction of iNKT cells, reducing hepatocyte death during ConA-mediated liver damage, thus protecting the mice from hepatitis.<\/jats:p><jats:p>NEW &amp; NOTEWORTHY The genetic inactivation of Parp2, but not Parp1, protects mice from concanavalin A hepatitis. Immune cell populations are lower in the thymus, but not in the spleen, liver, or bone marrow of Parp2-deficient mice compared with wild-type mice. Spleen and liver invariant natural killer T (NKT) lymphocytes, as well as thymic T and NKT lymphocytes, are reduced in Parp2-deficient mice.<\/jats:p>","DOI":"10.1152\/ajpgi.00436.2016","type":"journal-article","created":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T01:10:30Z","timestamp":1501204230000},"page":"G399-G409","source":"Crossref","is-referenced-by-count":13,"title":["PARP2 deficiency affects invariant-NKT-cell maturation and protects mice from concanavalin A-induced liver injury"],"prefix":"10.1152","volume":"313","author":[{"given":"Aveline","family":"Filliol","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Institut de Recherche Sant\u00e9 Environnement et Travail, Rennes, France;"},{"name":"Universit\u00e9 de Rennes 1, Rennes, France;"},{"name":"Structure F\u00e9d\u00e9rative BioSit, UMS 3480, Centre National de la Recherche Scientifique-US18 INSERM, Rennes, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Piquet-Pellorce","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Institut de Recherche Sant\u00e9 Environnement et Travail, Rennes, France;"},{"name":"Universit\u00e9 de Rennes 1, Rennes, France;"},{"name":"Structure F\u00e9d\u00e9rative BioSit, UMS 3480, Centre National de la Recherche Scientifique-US18 INSERM, Rennes, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Dion","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Institut de Recherche Sant\u00e9 Environnement et Travail, Rennes, France;"},{"name":"Universit\u00e9 de Rennes 1, Rennes, France;"},{"name":"Structure F\u00e9d\u00e9rative BioSit, UMS 3480, Centre National de la Recherche Scientifique-US18 INSERM, Rennes, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentine","family":"Genet","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Institut de Recherche Sant\u00e9 Environnement et Travail, Rennes, France;"},{"name":"Universit\u00e9 de Rennes 1, Rennes, France;"},{"name":"Structure F\u00e9d\u00e9rative BioSit, UMS 3480, Centre National de la Recherche Scientifique-US18 INSERM, Rennes, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Lucas-Clerc","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Rennes 1, Rennes, France;"},{"name":"Service de Biochimie Centre Hospitalier Universitaire de Rennes, Universit\u00e9 de Rennes 1, Rennes, France; 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