{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T17:24:08Z","timestamp":1787246648149,"version":"build-2736575974"},"reference-count":27,"publisher":"American Physiological Society","issue":"3","funder":[{"name":"Basic Science Research Program through the NRF of Korea","award":["2019R1C1C1006654"],"award-info":[{"award-number":["2019R1C1C1006654"]}]},{"name":"Basic Science Research Program through the NRF of Korea","award":["RS-2023-00210718"],"award-info":[{"award-number":["RS-2023-00210718"]}]},{"name":"Grant of Seoul National University Hospital","award":["0420190330"],"award-info":[{"award-number":["0420190330"]}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:p>\n                    Pelvic irradiation is associated with attenuated adenosine triphosphate (ATP)-mediated rectal smooth muscle relaxation. The loss of platelet-derived growth factor receptor alpha-positive (PDGFR\u03b1\n                    <jats:sup>+<\/jats:sup>\n                    ) cells is associated with altered rectal neuromodulation. PDGFR\u03b1\n                    <jats:sup>+<\/jats:sup>\n                    cells and interstitial cells of Cajal (ICC) are reduced in irradiated rectal tissue. Intrinsic smooth muscle contractile responses are preserved, whereas ATP-mediated inhibitory regulation is reduced.\n                  <\/jats:p>","DOI":"10.1152\/ajpgi.00451.2025","type":"journal-article","created":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T06:50:27Z","timestamp":1785567027000},"page":"G287-G298","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Radiotherapy reduces ATP-mediated relaxation in human rectal smooth muscle"],"prefix":"10.1152","volume":"331","author":[{"given":"Yoon-Hye","family":"Kwon","sequence":"first","affiliation":[{"name":"Uijeongbu Eulji Medical Center","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Sik","family":"Sung","sequence":"additional","affiliation":[{"name":"Kosin University College of Medicine","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Hyun","family":"Yun","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine","place":["Korea"]},{"name":"Eulji University School of Medicine","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunjin","family":"Jung","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine","place":["Korea"]},{"name":"Seoul National University College of Medicine, Seoul National University Hospital","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Insuk","family":"So","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6407-0444","authenticated-orcid":false,"given":"Seung-Bum","family":"Ryoo","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine, Seoul National University Hospital","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu Joo","family":"Park","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine, Seoul National University Hospital","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2024.0041"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2014.46"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.757973"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0171461"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-2744"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1093\/bjsopen\/zrae091"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.14.779"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2014.333"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800721107"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1007\/BF02236859"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2012.168"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2014.00078"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/0471141755.ph0415s48"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.5056\/jnm21117"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2011.01510.x"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.4196\/kjpp.2015.19.6.533"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.4196\/kjpp.2014.18.5.383"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2022.05.004"},{"key":"B20","first-page":"93","volume":"15","author":"Jun JY","year":"2009","journal-title":"Korean J Neurogastroenterol Motil"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2013.747695"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2016.02.054"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-016-4183-5"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1667\/RR14132.1"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12653"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00661"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.332"}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpgi.00451.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:26:39Z","timestamp":1787243199000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpgi.00451.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9,1]]}},"alternative-id":["10.1152\/ajpgi.00451.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.00451.2025","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]},"assertion":[{"value":"2025-12-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-12","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}