{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T11:06:17Z","timestamp":1784113577050,"version":"3.55.0"},"reference-count":30,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:p> Human and pig cDNAs for a novel stomach protein, the product of a gene expressed at high levels specifically in cells of the antrum mucosa, have been characterized. The general exon\/intron structure of the genomic DNA is conserved in humans and mice. The predicted protein sequences of the human and mouse mRNAs contain 185 and 184 amino acids, respectively. The protein isolated from pig antral extracts has an NH<jats:sub>2<\/jats:sub> terminus consistent with cleavage of a 20-amino acid signal peptide. Human cDNA was expressed in E. coli to generate a protein antigen for antibody production. The antibodies detected polypeptides of \u223c18 kDa in antrum extracts from all mammalian species tested. Immunocytochemistry located antrum mucosal protein (AMP)-18 to surface mucosal cells of the mouse antrum and, specifically, to secretion granules, suggesting that it is cosecreted with mucins. Antrum extracts and recombinant human AMP-18 exhibit growth-promoting activity on epithelial cells that can be blocked by the specific antisera. We suggest that AMP-18 is a \u201cgastrokine\u201d that maintains the integrity of the gastric mucosal epithelium. <\/jats:p>","DOI":"10.1152\/ajpgi.00453.2002","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T14:59:02Z","timestamp":1425394742000},"page":"G332-G343","source":"Crossref","is-referenced-by-count":74,"title":["A novel mitogenic protein that is highly expressed in cells of the  gastric antrum mucosa"],"prefix":"10.1152","volume":"285","author":[{"given":"Terence E.","family":"Martin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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Gary","family":"Toback","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"REF1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)91028-6"},{"key":"REF2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00591a005"},{"key":"REF3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.63.1.119"},{"key":"REF4","doi-asserted-by":"publisher","DOI":"10.2144\/99274bm04"},{"key":"REF5","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.39.4.353"},{"key":"REF6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.15.4662"},{"key":"REF7","unstructured":"Johnson FR and  McMinn RM. Microscopic structure of pyloric epithelium of the cat.  J Anat 107:  67\u201386, 1970."},{"key":"REF8","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001720303"},{"key":"REF9","unstructured":"Leser GP, Fakan  S, and Martin TE. 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Int J Oncol 19:  701\u2013707, 2001.","DOI":"10.3892\/ijo.19.4.701"},{"key":"REF22","doi-asserted-by":"publisher","DOI":"10.1172\/JCI3304"},{"key":"REF23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.9.5201"},{"key":"REF24","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.11.6654"},{"key":"REF25","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00048.2003"},{"key":"REF26","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.13.4764"},{"key":"REF27","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.5.577"},{"key":"REF28","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.4.1049"},{"key":"REF29","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/19.5.1073"},{"key":"REF30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2000.tb00967.x"}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpgi.00453.2002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T20:41:42Z","timestamp":1567975302000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpgi.00453.2002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,8]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,8]]}},"alternative-id":["10.1152\/ajpgi.00453.2002"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.00453.2002","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,8]]}}}