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Release of the protein appears to be regulated because forskolin decreased the amount of immunoreactive AMP-18 in primary cultures of canine antrum mucosal epithelial cells, and indomethacin gavaged into the stomach of mice reduced AMP-18 content in antrum mucosal tissue before inducing histological injury. A functional domain of the protein was identified by preparing peptides derived from the center of human AMP-18. A 21-mer peptide stimulated growth of gastric and intestinal epithelial cells, but not fibroblasts, and increased restitution of scrape-wounded gastric epithelial monolayers. These functions of AMP-18 suggest that its release onto the apical cell surface is regulated and that the protein and\/or peptide fragments may protect the antral mucosa and promote healing by facilitating restitution and proliferation after injury.<\/jats:p>","DOI":"10.1152\/ajpgi.00455.2002","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T19:59:02Z","timestamp":1425412742000},"page":"G344-G353","source":"Crossref","is-referenced-by-count":59,"title":["Peptide fragments of AMP-18, a novel secreted gastric antrum mucosal protein, are mitogenic and motogenic"],"prefix":"10.1152","volume":"285","author":[{"given":"F. 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