{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T03:53:09Z","timestamp":1782445989437,"version":"3.54.5"},"reference-count":25,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2003,5,1]]},"abstract":"<jats:p> This study investigates motilin effects on the proximal stomach in patients with functional dyspepsia (FD) and healthy volunteers. Eight healthy volunteers and 12 patients with FD were infused with synthetic motilin or placebo. Proximal gastric volume was measured with a barostat at constant pressure and during isobaric distensions. Abdominal symptoms were scored by visual analog scales. Plasma motilin concentrations were measured by radioimmunoassay. Motilin concentrations and baseline gastric volumes were similar for patients and healthy volunteers. Motilin, compared with placebo, reduced gastric volume by 112 ml [ F(29,195); confidence interval (CI) 95%] in patients and by 96 ml [ F(\u22127,200); CI 95%] in healthy volunteers. In patients, motilin decreased compliance by 76 ml\/mmHg [ F(9,143); CI 95%] compared with placebo, which was similar in volunteers [66 ml\/mmHg; F(11,120); CI 95%]. Patients were more nauseous during motilin compared with placebo ( P = 0.04), whereas healthy volunteers did not experience nausea. We conclude that in a fasted condition, FD patients have a similar proximal gastric motor response to motilin as healthy volunteers, but experience an exaggerated sensation of nausea. <\/jats:p>","DOI":"10.1152\/ajpgi.00456.2002","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T19:58:00Z","timestamp":1425412680000},"page":"G776-G781","source":"Crossref","is-referenced-by-count":23,"title":["Motilin effects on the proximal stomach in patients  with functional dyspepsia and healthy volunteers"],"prefix":"10.1152","volume":"284","author":[{"given":"Ingrid M. C.","family":"Kamerling","sequence":"first","affiliation":[{"name":"Centre for Human Drug Research, 2333 CL Leiden, The Netherlands,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aernout D.","family":"Van Haarst","sequence":"additional","affiliation":[{"name":"Centre for Human Drug Research, 2333 CL Leiden, The Netherlands,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacobus","family":"Burggraaf","sequence":"additional","affiliation":[{"name":"Centre for Human Drug Research, 2333 CL Leiden, The Netherlands,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rik C.","family":"Schoemaker","sequence":"additional","affiliation":[{"name":"Centre for Human Drug Research, 2333 CL Leiden, The Netherlands,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izak","family":"Biemond","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Leiden University Medical Center, 2333 AZ Leiden, The Netherlands; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hartmut","family":"Heinzerling","sequence":"additional","affiliation":[{"name":"Johnson and Johnson Pharmaceutical Research and Development, HP14 GT High Wycombe, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Jones","sequence":"additional","affiliation":[{"name":"Johnson and Johnson Pharmaceutical Research and Development, HP14 GT High Wycombe, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam F.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Centre for Human Drug Research, 2333 CL Leiden, The Netherlands,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ad A. 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