{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T22:31:41Z","timestamp":1778279501790,"version":"3.51.4"},"reference-count":32,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2003,7]]},"abstract":"<jats:p> Products of cyclooxygenase (COX)-2 contribute to mucosal defense. Acetylation of COX-2 by aspirin has been shown to result in the generation of 15(R)-epi-lipoxin A<jats:sub>4<\/jats:sub>, which exerts protective effects in the stomach. In gastritis, it is possible that lipoxin A<jats:sub>4<\/jats:sub> makes a greater contribution to mucosal defense. We tested this hypothesis in the rat, by using the iodoacetamide-induced gastritis model. Iodoacetamide was added to the drinking water for 5 days. Rats were then given aspirin, and the extent of gastric damage was blindly assessed 3 h later. Gastric 15(R)-epi-lipoxin A<jats:sub>4<\/jats:sub> and PGE<jats:sub>2<\/jats:sub> levels were determined. The effects of pretreatment with a selective COX-2 inhibitor, rofecoxib, and of a lipoxin receptor antagonist were assessed. Effects of aspirin and the other test drugs on leukocyte adherence within mesenteric venules were assessed by intravital microscopy. Aspirin elicited greater lipoxin synthesis in the inflamed than in the normal stomach, and there was reduced gastric damage. Rofecoxib inhibited lipoxin synthesis and exacerbated aspirin-induced damage. The lipoxin antagonist also exacerbated aspirin-induced damage. In rats with gastritis, aspirin reduced leukocyte adherence (in contrast to an increase in normal rats), and this effect was reversed by rofecoxib or by the lipoxin antagonist. These results support the notion that aspirin-triggered lipoxin synthesis via COX-2 makes an important contribution to mucosal defense in both the normal and inflamed stomach. <\/jats:p>","DOI":"10.1152\/ajpgi.00525.2002","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T14:58:13Z","timestamp":1425394693000},"page":"G54-G61","source":"Crossref","is-referenced-by-count":37,"title":["Gastritis increases resistance to aspirin-induced mucosal injury via  COX-2-mediated lipoxin synthesis"],"prefix":"10.1152","volume":"285","author":[{"given":"Marcellus H. L. P.","family":"Souza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Octavio Menezes","family":"de Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stella R.","family":"Zamuner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Fiorucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John L.","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"REF1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2000.279.6.G1292"},{"key":"REF2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.2002.00051.x"},{"key":"REF3","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(00)00637-9"},{"key":"REF4","unstructured":"Chiang N,  Takano T, Clish C, Petasis N, Tai HH, and Serhan C. 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