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Video recordings were used to construct spatiotemporal maps of spontaneous contractile patterns in colon from postnatal and adult mice in vitro. In Ret<jats:sup>+\/\u2212<\/jats:sup>and ET- 3<jats:sup>+\/\u2212<\/jats:sup>mice, which have normal numbers of enteric neurons, colonic migrating motor complexes (CMMCs) displayed similar properties under control conditions and following inhibition of nitric oxide synthase (NOS) activity to wild-type mice. In the colon of Gdnf<jats:sup>+\/\u2212<\/jats:sup>mice and in the ganglionic region of ET- 3<jats:sup>\u2212\/\u2212<\/jats:sup>mice, there was a 50\u201360% reduction in myenteric neuron number. In Gdnf<jats:sup>+\/\u2212<\/jats:sup>mice, CMMCs were present, but abnormal, and the proportion of myenteric neurons containing NOS was not different from that of wild-type mice. In the ganglionic region of postnatal ET- 3<jats:sup>\u2212\/\u2212<\/jats:sup>mice, CMMCs were absent, and the proportion of myenteric neurons containing NOS was over 100% higher than in wild-type mice. Thus impairments in spontaneous motility patterns in the colon of Gdnf<jats:sup>+\/\u2212<\/jats:sup>mice and in the ganglionic region of ET- 3<jats:sup>\u2212\/\u2212<\/jats:sup>mice are correlated with a reduction in myenteric neuron density.<\/jats:p>","DOI":"10.1152\/ajpgi.00558.2007","type":"journal-article","created":{"date-parts":[[2008,2,15]],"date-time":"2008-02-15T02:05:37Z","timestamp":1203041137000},"page":"G996-G1008","source":"Crossref","is-referenced-by-count":86,"title":["Disturbances of colonic motility in mouse models of Hirschsprung's disease"],"prefix":"10.1152","volume":"294","author":[{"given":"Rachael R.","family":"Roberts","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel C.","family":"Bornstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette 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