{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T07:03:16Z","timestamp":1649142196649},"reference-count":0,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[1980,8,1]]},"abstract":"<jats:p> Unidirectional fluxes of alanine, methionine, and Na were measured in jejunal segments from 3- to 4-wk-old normal (N) mice or mice with congenital (P) or induced (I) megacolon in the absence of electrochemical gradients. Short-circuit currents were 286.8 +\/- 16.3 and 302.1 +\/- 32.6 mu A\/cm2 for P and I mice, respectively, and were approximately 1.5-2 times greater than in N mice. Tissue conductances averaged 42.3 +\/- 0.6 and 39.3 +\/- 3.4 mS\/cm2 for P and I mice, respectively, and were twice those found in N mice. Net Na absorption was 2-3 times greater in P than N mice and was increased by addition of alanine. Alanine and methionine were actively absorbed and the net fluxes of alanine were 2-3 times greater in p and I mice than in normals. Unidirectional alanine influx was enhanced in P and I mice. Jmax of 9.7 +\/- 2.6 and 14.2 +\/- 1.0 micro M x cm-2 x h-1 were obtained for N and P mice, respectively. These results show that the transport properties of jejunal mucosa of mice with megacolon differ from those of N mice. Mice with megacolon absorb alanine and Na at a greater rate than N mice and the enhanced amino acid absorptive rate can be explained by an increased alanine influx, probably due to an increased number of active transport carriers. <\/jats:p>","DOI":"10.1152\/ajpgi.1980.239.2.g123","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T23:08:38Z","timestamp":1514070518000},"page":"G123-G127","source":"Crossref","is-referenced-by-count":0,"title":["Jejunal transport properties of piebald mouse model for Hirschsprung's disease"],"prefix":"10.1152","volume":"239","author":[{"given":"H. J.","family":"Cooke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"H. J.","family":"Henning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. D.","family":"Wood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. R.","family":"Cooke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpgi.1980.239.2.G123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T22:12:42Z","timestamp":1567980762000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpgi.1980.239.2.G123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1980,8,1]]}},"alternative-id":["10.1152\/ajpgi.1980.239.2.G123"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.1980.239.2.g123","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,8,1]]}}}