{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T08:57:34Z","timestamp":1648889854528},"reference-count":0,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[1982,8,1]]},"abstract":"<jats:p> The purpose of this study was to compare the effect of altering the extracellular calcium ion concentration on bethanechol or octapeptide of cholecystokinin (OP-CCK) stimulation of the isolated transverse colon of the cat. Myoelectric activity was recorded with monopolar glass-pore electrodes. Bethanechol (10(-6) M) stimulated an increase in the number of slow waves with superimposed spike potentials to 85.5 +\/- 5.3% (P less than 0.001) compared with the basal spike activity (8.9 +\/- 1.4%). OP-CCK (4 x 10(-9)) also increased spike activity (80.7 +\/- 3.8%, P less than 0.001), which was not inhibited by atropine, phentolamine, or propranolol. Addition of 0.0 mM calcium solution to the colonic smooth muscle abolished both slow-wave and spike activity, which returned after replacing 0.25 mM calcium in the solution. Bethanechol stimulated a greater increase in spike activity as the concentration of calcium was increased. OP-CCK stimulation of colonic spike activity was more sensitive to the extracellular calcium concentration than bethanechol stimulation. Verapamil had a minimal effect on bethanechol stimulation of colonic spike activity, but it inhibited the OP-CCK stimulation. These studies suggest that 1) OP-CCK appears to stimulate colonic smooth muscle directly and 2) OP-CCK requires the presence of a greater amount of extracellular ionic calcium in order to stimulate colonic spike activity compared with bethanechol. <\/jats:p>","DOI":"10.1152\/ajpgi.1982.243.2.g134","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T00:48:33Z","timestamp":1514076513000},"page":"G134-G140","source":"Crossref","is-referenced-by-count":0,"title":["Effect of calcium on neurohumoral stimulation of feline colonic smooth muscle"],"prefix":"10.1152","volume":"243","author":[{"suffix":"Jr","given":"W. J.","family":"Snape","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpgi.1982.243.2.G134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T22:27:49Z","timestamp":1567981669000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpgi.1982.243.2.G134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1982,8,1]]}},"alternative-id":["10.1152\/ajpgi.1982.243.2.G134"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.1982.243.2.g134","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,8,1]]}}}