{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T21:41:08Z","timestamp":1648676468794},"reference-count":0,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[1983,6,1]]},"abstract":"<jats:p> Extracellular unitary recordings were made from neurons in the rat dorsal vagal nucleus, and the response of these neurons to iontophoretically applied cholecystokinin octapeptide (CCK-OP) and proglumide (a novel CCK antagonist) was studied. The effect of CCK-OP and proglumide on the response of the neurons to gastric distension was also studied. Seventy-four percent (n = 39) of the neurons studied were excited by CCK-OP. It was not possible to antagonize the response to CCK-OP with proglumide. CCK-OP was also found to be an effective modulator of the response to gastric distension; the effects were diverse (\u201con\u201d responses were augmented; \u201doff\u201c and \u201ctransient\u201d responses were diminished) but were always the same within each characteristic pattern of response to distension. These results provide supporting evidence for CCK-OP, a peptide common to both brain and gut, acting in the role of a neural modulator in the control of the gastrointestinal tract. It is possible to speculate that the potent effect of CCK-OP on neuronal excitability and on the central representation of gastric mechanoreceptor activity may well substantiate the role of CCK-OP as a central regulator of feeding behavior. <\/jats:p>","DOI":"10.1152\/ajpgi.1983.244.6.g613","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T19:36:20Z","timestamp":1514057780000},"page":"G613-G617","source":"Crossref","is-referenced-by-count":4,"title":["Cholecystokinin octapeptide and gastric mechanoreceptor activity in rat brain"],"prefix":"10.1152","volume":"244","author":[{"given":"W. R.","family":"Ewart","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. L.","family":"Wingate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpgi.1983.244.6.G613","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T18:24:10Z","timestamp":1567967050000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpgi.1983.244.6.G613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1983,6,1]]}},"alternative-id":["10.1152\/ajpgi.1983.244.6.G613"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.1983.244.6.g613","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,6,1]]}}}