{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T23:24:21Z","timestamp":1648769061595},"reference-count":0,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[1983,10,1]]},"abstract":"<jats:p> Previously, an electrogenic Na-Cl symport was found in the fundus, and the question arises of whether there is one in the antrum, a tissue that does not secrete acid. In an in vitro preparation of the antrum of Rana catesbeiana, we found that when the [Na+] in nutrient solution was decreased (choline for Na+) the transmucosal potential difference (PD) decreased (the positivity of nutrient side decreased), and when the [Na+] was increased the PD increased. These PD changes were anomalous for Na+ but not for choline. A linear relationship for PD versus log [Na+] and not versus log [choline] excluded a choline conductive pathway. The anomalous PD response was decreased but not abolished by 10(-3) M ouabain. Normal PD responses resulted from [Na+] changes in Cl--free (SO2-4) solutions. PD responses to changes in nutrient [Cl-] were normal but decreased in the absence of Na+. Data are compatible with a passive electrogenic Na-Cl symport with more chloride than sodium ions transported per cycle, as in the fundus. Symport conductance-to-total Cl- conductance ratio is higher in antrum than in the fundus. Data from the luminal side were compatible with apical membrane conductances for Na+ and Cl-. <\/jats:p>","DOI":"10.1152\/ajpgi.1983.245.4.g554","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T00:02:12Z","timestamp":1514073732000},"page":"G554-G561","source":"Crossref","is-referenced-by-count":2,"title":["Anomalous potential difference responses to changes in sodium concentration in the antrum of frog stomach"],"prefix":"10.1152","volume":"245","author":[{"given":"G.","family":"Carrasquer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Kissel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. S.","family":"Rehm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpgi.1983.245.4.G554","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T22:21:31Z","timestamp":1567981291000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpgi.1983.245.4.G554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1983,10,1]]}},"alternative-id":["10.1152\/ajpgi.1983.245.4.G554"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.1983.245.4.g554","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,10,1]]}}}