{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T14:05:56Z","timestamp":1789826756345,"version":"4.0.1"},"reference-count":0,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[1984,2,1]]},"abstract":"<jats:p> To determine the relative effects of systemic pH, PCO2, and bicarbonate concentration on colonic electrolyte transport, states of acute metabolic acidosis and alkalosis were created in Sprague-Dawley rats by gavage feeding (NH4)2SO4 and NaHCO3, respectively. During in situ perfusion of the distal colon in pentobarbital-anesthetized animals, electrolyte transport was measured before and after respiratory compensation of the systemic pH. Acute respiratory acidosis and alkalosis also were studied by ventilating animals with 0, 3, or 8% CO2. When animals in all groups were considered, net sodium absorption correlated well with blood PCO2 (r = 0.99) but not with blood pH. Net bicarbonate secretion correlated with the plasma (r = 0.95) and luminal (r = -0.63) bicarbonate concentrations but not with blood pH or PCO2. Net chloride absorption correlated with both blood PCO2 (r = 0.92) and the plasma bicarbonate concentration (r = 0.80). These results suggest that systemic PCO2 affects a sodium chloride absorptive process and that the plasma bicarbonate concentration affects a chloride absorptive-bicarbonate secretory exchange process in the rat colon. <\/jats:p>","DOI":"10.1152\/ajpgi.1984.246.2.g159","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T19:29:55Z","timestamp":1514057395000},"page":"G159-G165","source":"Crossref","is-referenced-by-count":7,"title":["Relative effects of systemic pH, PCO2, and HCO3 concentration on colonic ion transport"],"prefix":"10.1152","volume":"246","author":[{"given":"A. N.","family":"Charney","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. P.","family":"Haskell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpgi.1984.246.2.G159","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T21:37:26Z","timestamp":1567978646000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpgi.1984.246.2.G159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1984,2,1]]}},"alternative-id":["10.1152\/ajpgi.1984.246.2.G159"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.1984.246.2.g159","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,2,1]]}}}