{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T01:54:40Z","timestamp":1655430880802},"reference-count":0,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[1985,2,1]]},"abstract":"<jats:p> We investigated the effects of prostaglandins (PG) of E, F, and I series and their stable analogues on gastric acid secretion, serum gastrin level, and growth of gastroduodenal mucosa and pancreas in rats. Short-term administration (every 8 h for 48 h) of E and F series PGs and their stable analogues caused significant stimulation of DNA synthesis; prolonged PG treatment (every 8 h for 10 days) significantly increased weight and total DNA and RNA contents of the organs tested. PGs of E series were given in doses that inhibited gastric acid secretion about 50% and raised serum gastrin significantly; PGs of F series were injected in the same dose (1,000 micrograms\/kg) as PGs of E series but did not affect acid secretion or serum gastrin. Short- or long-term treatment with PGI2 or its stable analogue (Hoe 892), injected in doses causing about 50% inhibition of acid secretion and significant increments in serum gastrin levels, failed to affect any of the growth-related parameters in the stomach, duodenum, or pancreas. We conclude that PGs of E and F (but not of I) series exhibit a marked stimulatory influence on growth of gastroduodenal mucosa and pancreas. These trophic effects appear to be unrelated to gastric secretion or serum gastrin release. <\/jats:p>","DOI":"10.1152\/ajpgi.1985.248.2.g170","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T15:17:24Z","timestamp":1514042244000},"page":"G170-G175","source":"Crossref","is-referenced-by-count":2,"title":["Effects of E, F, and I series prostaglandins and analogues on growth of gastroduodenal mucosa and pancreas"],"prefix":"10.1152","volume":"248","author":[{"given":"A.","family":"Dembinski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. J.","family":"Konturek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpgi.1985.248.2.G170","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T17:42:45Z","timestamp":1567964565000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpgi.1985.248.2.G170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1985,2,1]]}},"alternative-id":["10.1152\/ajpgi.1985.248.2.G170"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.1985.248.2.g170","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,2,1]]}}}