{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T17:42:39Z","timestamp":1698082959676},"reference-count":0,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[1985,11,1]]},"abstract":"<jats:p> The role of peripheral and central opioid receptors in morphine-induced migrating myoelectric complexes (MMECs) was studied in conscious dogs implanted with silver-silver chloride electrodes. In normal fasted dogs morphine (100-200 micrograms\/kg iv) initiated phase III of the MMEC in the duodenum. Once initiated the MMEC propagated distally. This effect of morphine was blocked by the opioid receptor antagonists naloxone (2 mg\/kg iv) and N,N-diallylnormorphinium bromide (4 mg\/kg iv). Higher doses of morphine (300-600 micrograms\/kg iv) initiated phase III activity in fed dogs as early as 20 min after feeding, while lower doses (150 micrograms\/kg iv) initiated phase III activity routinely when administered 100 min after feeding. In dogs with bilateral vagotomies and bilateral thoracolumbar sympathetic chain ganglionectomies, morphine (150 micrograms\/kg iv) initiated phase III activity in the duodenum, which then migrated distally. This study demonstrates that morphine initiates phase III of the MMEC by acting through peripheral opioid receptors. <\/jats:p>","DOI":"10.1152\/ajpgi.1985.249.5.g557","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T21:24:56Z","timestamp":1514064296000},"page":"G557-G562","source":"Crossref","is-referenced-by-count":1,"title":["Morphine initiates migrating myoelectric complexes by acting on peripheral opioid receptors"],"prefix":"10.1152","volume":"249","author":[{"given":"G. L.","family":"Telford","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Hoshmonai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J.","family":"Moses","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. H.","family":"Szurszewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpgi.1985.249.5.G557","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T21:50:33Z","timestamp":1567979433000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpgi.1985.249.5.G557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,11,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1985,11,1]]}},"alternative-id":["10.1152\/ajpgi.1985.249.5.G557"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.1985.249.5.g557","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,11,1]]}}}