{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T11:57:59Z","timestamp":1648814279573},"reference-count":0,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[1987,8,1]]},"abstract":"<jats:p> Total and regional splanchnic blood flows were measured with radiolabeled microspheres (15 micron) in one-kidney, one-clip renal hypertensive rats at 2, 4, and 6 wk after induction of hypertension. Arterial pressures (mean +\/- SE, mmHg) for the normotensive rats (N) and age-matched hypertensive rats (H) were 110 +\/- 5 and 114 +\/- 6 at 2 wk, 104 +\/- 4 and 148 +\/- 13 at 4 wk, and 117 +\/- 6 and 164 +\/- 11 at 6 wk, respectively. Total splanchnic blood flow was increased in H compared with N at 4 wk but not at 2 or 6 wk. The blood flow changes among individual splanchnic organs varied in N and H. For example, at 2 and 4 wk, stomach, small intestine, large intestine, pancreas, hepatic artery, and portal venous blood flows in H were unchanged compared with N. At 6 wk, small intestinal and hepatic arterial blood flows were increased in H compared with N, and pancreatic blood flow was decreased. Vascular resistance was not different for any splanchnic organs between N and H at 2 wk, but it was elevated in H for all organs at 4 and 6 wk except for the hepatic artery. In another group of rats, the renal and superior mesenteric arteries (SMA) were instrumented with ultrasonic Doppler flow probes. Acute one-kidney, one-clip hypertension was produced by removing one kidney and mechanically reducing flow to the remaining kidney with a pneumatic occluder. After 2 h of stenosis, mean arterial pressure and SMA flow velocity was decreased by 6%.(ABSTRACT TRUNCATED AT 250 WORDS) <\/jats:p>","DOI":"10.1152\/ajpgi.1987.253.2.g146","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T16:48:21Z","timestamp":1514047701000},"page":"G146-G154","source":"Crossref","is-referenced-by-count":0,"title":["Splanchnic circulatory changes during development of renal hypertension"],"prefix":"10.1152","volume":"253","author":[{"given":"G. A.","family":"Meininger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. N.","family":"Benoit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. Z.","family":"Ostrowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. K.","family":"Muckleroy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpgi.1987.253.2.G146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T17:53:12Z","timestamp":1567965192000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpgi.1987.253.2.G146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1987,8,1]]}},"alternative-id":["10.1152\/ajpgi.1987.253.2.G146"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.1987.253.2.g146","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,8,1]]}}}