{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T20:58:51Z","timestamp":1762376331474},"reference-count":0,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[1988,2,1]]},"abstract":"<jats:p> In vivo secretion of gastric acid and pepsin has been studied in pylorus-ligated cod. Basal acid output amounted to 100-150 mumol H+.kg-1.h-1 and pepsin secretion to 1 mg.kg-1.h-1. In response to bombesin nonapeptide (2.4 nmol.kg-1.h-1) and histamine (81 nmol.kg-1.h-1), acid secretion increased to approximately 200 and 600% of the basal level, respectively. Pepsin output was marginally affected by histamine but increased to approximately 3 and 15 times the basal level during treatment with bombesin and eledoisin (3.27 nmol.kg-1.h-1). Somatostatin (SS-14, 15 nmol.kg-1.h-1) inhibited basal acid secretion by 85%. It also inhibited the acid secretion during stimulation with bombesin (68%) and histamine (57%), but although the former effect could be explained by removal of the basal component, the latter could not. Basal pepsin secretion was not affected by SS-14. A slight inhibition (28%) of the peak pepsin response to eledoisin was demonstrated, and bombesin failed to stimulate pepsin secretion during treatment with SS-14. These results indicate that endogenous somatostatin, if present in the cod stomach, could play a role in the regulation of gastric secretion. <\/jats:p>","DOI":"10.1152\/ajpgi.1988.254.2.g183","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T05:32:40Z","timestamp":1514093560000},"page":"G183-G188","source":"Crossref","is-referenced-by-count":1,"title":["Effect of somatostatin on basal and stimulated gastric secretion in the cod, Gadus morhua"],"prefix":"10.1152","volume":"254","author":[{"given":"B.","family":"Holstein","sequence":"first","affiliation":[{"name":"Department of Zoophysiology, University of Goteborg, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Cederberg","sequence":"additional","affiliation":[{"name":"Department of Zoophysiology, University of Goteborg, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpgi.1988.254.2.G183","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T23:05:29Z","timestamp":1567983929000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpgi.1988.254.2.G183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1988,2,1]]}},"alternative-id":["10.1152\/ajpgi.1988.254.2.G183"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.1988.254.2.g183","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,2,1]]}}}