{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:05:05Z","timestamp":1790744705481,"version":"4.1.0"},"reference-count":0,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[1988,9,1]]},"abstract":"<jats:p> In 18 anesthetized dogs, antroduodenal and pyloric motility was monitored in vivo by a sleeve and perfused side-hole manometric assembly and by antral and duodenal serosal strain gauges. Close intra-arterial injection to the pylorus of dynorphin-(1-13) (Dyn) for kappa-receptors, [D-Pen2,5]enkephalin (DPen2,5-Enk) for delta-receptors, and [N-Me-Phe3-D-Pro4]morphiceptin (PL017) and [D-Ala2,N-Me-Phe4,Gly5-ol]enkephalin (DAGO) for mu-receptors showed no excitatory effect in the pylorus. When pyloric motor activity was increased by duodenal field stimulation 3-5 cm aboaad from the pylorus, Dyn greater than DPen2,5-Enk greater than DAGO produced a dose-dependent inhibition of the pyloric motor activity. Naloxone (200 micrograms\/kg iv and 20 micrograms ia) had no effect on the pyloric excitation due to duodenal field stimulation, but it reduced the inhibitory response of intra-arterially injected opioids. In addition, opioid binding ([3H]diprenorphine) in microsomal and mitochondrial fractions from the inner circular muscle ring of the pylorus showed a distribution similar to the neuronal marker [3H]saxitoxin but no correlation to the plasma membrane marker 5'-nucleotidase. These results suggest the existence of inhibitory opioid receptors (kappa- and delta-receptors) on excitatory neurons in the intestinal neuronal pathway, which activates the canine pylorus. <\/jats:p>","DOI":"10.1152\/ajpgi.1988.255.3.g352","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T06:31:17Z","timestamp":1514097077000},"page":"G352-G360","source":"Crossref","is-referenced-by-count":1,"title":["Inhibitory opioid receptors in canine pylorus"],"prefix":"10.1152","volume":"255","author":[{"given":"H. D.","family":"Allescher","sequence":"first","affiliation":[{"name":"Department of Neurosciences, McMaster University, Hamilton, Ontario,Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, McMaster University, Hamilton, Ontario,Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. E.","family":"Daniel","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, McMaster University, Hamilton, Ontario,Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Dent","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, McMaster University, Hamilton, Ontario,Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Kostolanska","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, McMaster University, Hamilton, Ontario,Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. E.","family":"Fox","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, McMaster University, Hamilton, Ontario,Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpgi.1988.255.3.G352","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T23:16:30Z","timestamp":1567984590000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpgi.1988.255.3.G352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1988,9,1]]}},"alternative-id":["10.1152\/ajpgi.1988.255.3.G352"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.1988.255.3.g352","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,9,1]]}}}