{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T09:45:40Z","timestamp":1743414340366},"reference-count":0,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[1989,4,1]]},"abstract":"<jats:p> We examined regulation of histamine release from canine hepatic and fundic mucosal mast cells in short-term culture. We found that beta- but not alpha-adrenergic agonists markedly inhibited concanavalin A (ConA)-stimulated histamine release. Inhibition by epinephrine was reversed by the beta-antagonist propranolol, but not by the alpha-adrenergic antagonists phentolamine or yohimbine. The beta 2-selective antagonist ICI 115881 reversed the effects of epinephrine, whereas the beta 1-antagonists practolol and betaxolol had little effect. Prostaglandin E2 (PGE2), but not its analogue enprostil, inhibited ConA-stimulated histamine release. This difference may relate to the ability of PGE2, but not enprostil, to stimulate adenosine 3',5'-cyclic monophosphate (cAMP) production. Forskolin, cAMP analogues, and the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine also effectively inhibited ConA-stimulated histamine release. Neither adrenergic agonists nor PGE2 inhibited histamine release stimulated by the combination of phorbol 12-myristate-13-acetate plus the calcium ionophore A23187. These data suggest that inhibition was mediated via cAMP-dependent mechanisms and was exerted on primary cell activation, rather than on postreceptor activating events. <\/jats:p>","DOI":"10.1152\/ajpgi.1989.256.4.g727","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T00:46:25Z","timestamp":1514076385000},"page":"G727-G732","source":"Crossref","is-referenced-by-count":0,"title":["Beta-adrenergic and prostanoid inhibition of canine fundic mucosal mast cells"],"prefix":"10.1152","volume":"256","author":[{"given":"A. H.","family":"Soll","sequence":"first","affiliation":[{"name":"Center for Ulcer Research and Education, Veterans AdministrationWadsworth Hospital Center, Los Angeles, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Toomey","sequence":"additional","affiliation":[{"name":"Center for Ulcer Research and Education, Veterans AdministrationWadsworth Hospital Center, Los Angeles, California."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpgi.1989.256.4.G727","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T19:09:56Z","timestamp":1567969796000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpgi.1989.256.4.G727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1989,4,1]]}},"alternative-id":["10.1152\/ajpgi.1989.256.4.G727"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.1989.256.4.g727","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,4,1]]}}}