{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T23:14:09Z","timestamp":1648509249871},"reference-count":0,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[1991,8,1]]},"abstract":"<jats:p> The properties of K+ channels in the isolated oxyntic cells of the bullfrog (Rana catesbeiana) were investigated using the patch-clamp method. Two types of K+ channels on the basolateral membrane were identified on the basis of their electrophysiological and pharmacological properties. The K+ channel most frequently observed has a single-channel conductance of 61.0 +\/- 2.9 pS (n = 10) and is activated by an increase in intracellular Ca2+. The other K+ channel has a single-channel conductance of 30.3 +\/- 2.7 pS (n = 7), which is activated by adenosine 3',5'-cyclic monophosphate (cAMP). The physiological and pharmacological characteristics common to the two K+ channels are inward-going rectification with a high selectivity for K+ and indirect inhibition by omeprazole. The inward rectification is controlled by intracellular Mg2+ in such a way that the more Mg2+ is applied intracellularly, the more their inward-rectifying property is enhanced. The finding that bethanechol and cAMP increase the open probability of these K+ channels as well as activating the acid secretion indicates that there may be a relationship between these two processes in the oxyntic cells. <\/jats:p>","DOI":"10.1152\/ajpgi.1991.261.2.g206","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T20:12:49Z","timestamp":1514059969000},"page":"G206-G212","source":"Crossref","is-referenced-by-count":1,"title":["Electrical characteristics of inward-rectifying K+ channels in isolated bullfrog oxyntic cells"],"prefix":"10.1152","volume":"261","author":[{"given":"H.","family":"Mieno","sequence":"first","affiliation":[{"name":"First Department of Internal Medicine, Hiroshima University School ofMedicine, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Kajiyama","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Hiroshima University School ofMedicine, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpgi.1991.261.2.G206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T18:32:14Z","timestamp":1567967534000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpgi.1991.261.2.G206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1991,8,1]]}},"alternative-id":["10.1152\/ajpgi.1991.261.2.G206"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.1991.261.2.g206","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,8,1]]}}}