{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T03:29:17Z","timestamp":1752550157360},"reference-count":0,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[1991,8,1]]},"abstract":"<jats:p> The objectives of this study were 1) to quantify the effects of misoprostol (Miso; prostaglandin E1 analogue) on acetic acid-induced increases in mucosal permeability and inflammation; 2) to determine what effect acetic acid, Miso, or the combination of Miso plus acetic acid has on colonic blood flow; and 3) to assess whether the protective effect of Miso may be attributable to its vasodilatory properties. We found that intrarectal administration of acetic acid produced a 6.4-fold increase in colonic myeloperoxidase activity (an index of granulocyte infiltration), an 8.2-fold increase in mucosal permeability, a 1.6-fold increase in colonic weight, and a 6.8% decrease in body weight 48 h after enema. Miso pretreatment significantly attenuated the increases in colonic myeloperoxidase activity, mucosal permeability, and colon weight as well as prevented the loss of body weight. In a different series of experiments, we found that blood flow in the descending, transverse, and ascending colon increased 2.5- to 3.5-fold immediately after the acetic acid enema; however, it returned to control values at 1 and 4 h after enema. Miso pretreatment, followed by acetic acid, resulted in a further increase (2.5-fold) in blood flow in the descending colon 1 h after enema compared with acetic acid alone. This Miso-induced increase in blood flow at 1 h could not account for its protective effect inasmuch as colonic mucosal permeability (i.e., injury) in Miso-pretreated animals was not significantly different from values obtained in animals pretreated with vehicle and then given the enema. <\/jats:p>","DOI":"10.1152\/ajpgi.1991.261.2.g332","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T20:12:49Z","timestamp":1514059969000},"page":"G332-G339","source":"Crossref","is-referenced-by-count":3,"title":["Misoprostol attenuates acetic acid-induced increases in mucosal permeability and inflammation: role of blood flow"],"prefix":"10.1152","volume":"261","author":[{"given":"T.","family":"Yamada","sequence":"first","affiliation":[{"name":"Departments of Physiology and Biophysics, Louisiana State UniversityMedical Center, Shreveport 71130."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. D.","family":"Specian","sequence":"additional","affiliation":[{"name":"Departments of Physiology and Biophysics, Louisiana State UniversityMedical Center, Shreveport 71130."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. N.","family":"Granger","sequence":"additional","affiliation":[{"name":"Departments of Physiology and Biophysics, Louisiana State UniversityMedical Center, Shreveport 71130."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. S.","family":"Gaginella","sequence":"additional","affiliation":[{"name":"Departments of Physiology and Biophysics, Louisiana State UniversityMedical Center, Shreveport 71130."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. B.","family":"Grisham","sequence":"additional","affiliation":[{"name":"Departments of Physiology and Biophysics, Louisiana State UniversityMedical Center, Shreveport 71130."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpgi.1991.261.2.G332","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T18:32:23Z","timestamp":1567967543000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpgi.1991.261.2.G332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1991,8,1]]}},"alternative-id":["10.1152\/ajpgi.1991.261.2.G332"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.1991.261.2.g332","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"type":"print","value":"0193-1857"},{"type":"electronic","value":"1522-1547"}],"subject":[],"published":{"date-parts":[[1991,8,1]]}}}