{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T16:59:43Z","timestamp":1648918783331},"reference-count":0,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[1992,4,1]]},"abstract":"<jats:p> Antropyloroduodenal motility was recorded in seven anesthetized dogs to assess the role of nitric oxide and L-arginine metabolites in nonadrenergic noncholinergic (NANC) mediation of pyloric relaxation. Pyloric activity induced by duodenal field stimulation was inhibited by antral field stimulation and electrical vagal stimulation. Intra-arterial NG-L-arginine-methyl-ester (L-NAME) reduced the inhibition from antral or vagal stimulation (P less than 0.05). Intravenous infusion of L-NAME also blocked the inhibitory effect of vagal and antral stimulation but left the tetrodotoxin-insensitive action of intra-arterial vasoactive intestinal peptide (VIP) and sodium nitroprusside unchanged. L-Arginine reversed the effect of L-NAME whereas D-arginine did not. L-NAME enhanced pyloric contractions to intra-arterial acetylcholine. The NANC inhibition of the substance P-stimulated pyloric response in vitro was blocked by L-NAME and reversed by addition of L-arginine. Sodium nitroprusside was effective as a relaxant in vitro but VIP was not. These data suggest that metabolites of L-arginine mediate neural inhibition of canine pyloric motor activity. <\/jats:p>","DOI":"10.1152\/ajpgi.1992.262.4.g695","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T02:46:13Z","timestamp":1514083573000},"page":"G695-G702","source":"Crossref","is-referenced-by-count":8,"title":["Nitric oxide as a putative nonadrenergic noncholinergic inhibitory transmitter in the canine pylorus in vivo"],"prefix":"10.1152","volume":"262","author":[{"given":"H. D.","family":"Allescher","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, McMaster University, West Hamilton,Ontario, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Tougas","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, McMaster University, West Hamilton,Ontario, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Vergara","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, McMaster University, West Hamilton,Ontario, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, McMaster University, West Hamilton,Ontario, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. E.","family":"Daniel","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, McMaster University, West Hamilton,Ontario, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpgi.1992.262.4.G695","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T22:45:34Z","timestamp":1567982734000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpgi.1992.262.4.G695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1992,4,1]]}},"alternative-id":["10.1152\/ajpgi.1992.262.4.G695"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.1992.262.4.g695","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,4,1]]}}}