{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T12:41:54Z","timestamp":1725367314093},"reference-count":0,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[1992,9,1]]},"abstract":"<jats:p> It has been established that interleukin-1 beta (IL-1 beta) injected into the cerebrospinal fluid inhibits gastric acid secretion in rats. Brain sites of action of IL-1 beta were investigated in conscious rats implanted unilaterally with chronic hypothalamic cannula. Gastric acid secretion was monitored 2 h after pylorus ligation. Human recombinant IL-1 beta (10 ng) microinjected into the medial preoptic area, anterior hypothalamus, and paraventricular nucleus inhibited gastric acid secretion by 76-83%. IL-1 beta microinjected into the ventromedial hypothalamus and other hypothalamic sites outside of responsive sites had no effect. IL-1 beta inhibitory action in the medial preoptic area was dose related (0.1-10 ng), prevented by indomethacin (5 mg\/kg ip), and mimicked by prostaglandin E2. These results show that IL-1 beta acts in the medial preoptic area\/anterior hypothalamus and paraventricular nucleus to inhibit acid secretion in pylorus-ligated rats and that IL-1 beta action is likely to involve prostaglandin E2. <\/jats:p>","DOI":"10.1152\/ajpgi.1992.263.3.g414","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T02:42:56Z","timestamp":1514083376000},"page":"G414-G418","source":"Crossref","is-referenced-by-count":2,"title":["Interleukin-1 beta acts at hypothalamic sites to inhibit gastric acid secretion in rats"],"prefix":"10.1152","volume":"263","author":[{"given":"E.","family":"Saperas","sequence":"first","affiliation":[{"name":"Center for Ulcer Research and Education, Veteran's Affairs WadsworthMedical Center, Los Angeles, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Yang","sequence":"additional","affiliation":[{"name":"Center for Ulcer Research and Education, Veteran's Affairs WadsworthMedical Center, Los Angeles, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Tache","sequence":"additional","affiliation":[{"name":"Center for Ulcer Research and Education, Veteran's Affairs WadsworthMedical Center, Los Angeles, California."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpgi.1992.263.3.G414","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T22:40:23Z","timestamp":1567982423000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpgi.1992.263.3.G414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1992,9,1]]}},"alternative-id":["10.1152\/ajpgi.1992.263.3.G414"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.1992.263.3.g414","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,9,1]]}}}