{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T21:02:38Z","timestamp":1757451758840},"reference-count":0,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[1992,12,1]]},"abstract":"<jats:p> Intracellular recording methods were used to study the actions of 5-hydroxytryptamine (5-HT) on 257 myenteric neurons in the guinea pig gastric antrum. Application of 5-HT caused three types of postsynaptic responses. A fast-activating depolarizing response was accompanied by a decreased input resistance and desensitized quickly to repeated applications. It was mediated by a 5-HT3 receptor. A slowly activating depolarization, accompanied by an increase in the input resistance and enhancement of the excitability, was mainly observed in after hyperpolarizing\/type 2 neurons. It was suppressed by the prokinetic benzamide compound renzapride, while classical 5-HT1-4 receptor antagonists had no effect, suggesting the involvement of a 5-HT1p receptor as described in small intestinal neurons. A long-lasting hyperpolarizing response, accompanied by a decreased input resistance, was observed in a small subset of neurons. This response seemed to be mediated by a 5-HT1a receptor. Superfusion of 5-HT caused a dose-dependent inhibition of the stimulus-evoked nicotinic cholinergic fast excitatory postsynaptic potential (EPSP), which was mediated by a presynaptic 5-HT1a receptor. 5-HT also presynaptically inhibited the slow EPSP. <\/jats:p>","DOI":"10.1152\/ajpgi.1992.263.6.g838","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T22:25:27Z","timestamp":1514067927000},"page":"G838-G846","source":"Crossref","is-referenced-by-count":6,"title":["Actions of 5-hydroxytryptamine on myenteric neurons in guinea pig gastric antrum"],"prefix":"10.1152","volume":"263","author":[{"given":"J. F.","family":"Tack","sequence":"first","affiliation":[{"name":"Department of Physiology, College of Medicine, Ohio State University,Columbus 43210."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Janssens","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Medicine, Ohio State University,Columbus 43210."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Vantrappen","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Medicine, Ohio State University,Columbus 43210."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. D.","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Medicine, Ohio State University,Columbus 43210."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpgi.1992.263.6.G838","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T18:49:39Z","timestamp":1567968579000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpgi.1992.263.6.G838"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1992,12,1]]}},"alternative-id":["10.1152\/ajpgi.1992.263.6.G838"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.1992.263.6.g838","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,12,1]]}}}