{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T07:09:09Z","timestamp":1760080149419},"reference-count":0,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[1993,1,1]]},"abstract":"<jats:p> We examined the ability of human recombinant interleukin-1 beta (hrIL-1 beta) to alter the release of [3H]norepinephrine ([3H]NE) by KCl or electrical field stimulation in longitudinal muscle-myenteric plexus of rat intestine. The cytokine had no immediate effect on either the basal or evoked release of [3H]NE. However, hrIL-1 beta caused a biphasic time-dependent suppression of evoked [3H]NE release that was delayed in onset. IL-1 beta also stimulated the cycloheximide-sensitive uptake of [35S] methionine uptake by the tissue. The initial suppression of [3H]NE release was observed after 30 min and could not be inhibited by cycloheximide. A delayed peak was observed after 120 min and was inhibited by cycloheximide. The effect of IL-1 beta was maximal at 10 ng\/ml and could be prevented by a neutralizing anti-IL-1 beta antibody or by preincubating the tissue with an IL-1-receptor antagonist. These results indicate that IL-1 beta suppresses [3H]NE release from rat myenteric plexus by two mechanisms, one of which is independent of protein synthesis and the other of which is mediated by endogenous IL-1. <\/jats:p>","DOI":"10.1152\/ajpgi.1993.264.1.g30","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T03:41:21Z","timestamp":1514086881000},"page":"G30-G35","source":"Crossref","is-referenced-by-count":10,"title":["Interleukin-1 beta modulation of norepinephrine release from rat myenteric nerves"],"prefix":"10.1152","volume":"264","author":[{"given":"S.","family":"Hurst","sequence":"first","affiliation":[{"name":"Intestinal Diseases Research Unit, McMaster University, Hamilton,Ontario, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. M.","family":"Collins","sequence":"additional","affiliation":[{"name":"Intestinal Diseases Research Unit, McMaster University, Hamilton,Ontario, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpgi.1993.264.1.G30","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T22:50:36Z","timestamp":1567983036000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpgi.1993.264.1.G30"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1993,1,1]]}},"alternative-id":["10.1152\/ajpgi.1993.264.1.G30"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.1993.264.1.g30","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,1,1]]}}}