{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T10:26:41Z","timestamp":1648722401391},"reference-count":0,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[1994,7,1]]},"abstract":"<jats:p> Gastric acidification at pH 1.0 strongly inhibits the spontaneously occurring and motilin-induced phase III contractions in canine and human stomach. In this study, we examined inhibition by gastric acidification in dogs following gastrojejunostomy, truncal vagotomy, and antrectomy. As a result, gastric acidification with 0.1 N HCl solution at pH 1.0 for 30 min at a rate of 1.0 ml\/min significantly inhibited motilin-induced phase III activity to 23.5 +\/- 5.9% of the control in the normal intact dogs and to 17.2 +\/- 3.4% in the gastrojejunostomized dogs. In the antrectomized dogs, gastric acidification did not significantly inhibit the action of motilin (81.7 +\/- 10%), but, in the vagotomized dogs, gastric acidification inhibited the action of motilin to 72.0 +\/- 4.9%; the inhibition was much weaker than in the intact and gastrojejunostomized dogs but was significant. The duodenal acidification had no effect at all on the action of motilin (94.6 +\/- 12.5%) in the gastrojejunostomized dogs. These findings strongly suggest the existence of a vagovagal reflex in the inhibition of motilin-induced phase III contractions by gastric antral acidification, although the involvement of sympathetic regulation cannot be completely ruled out. <\/jats:p>","DOI":"10.1152\/ajpgi.1994.267.1.g129","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T10:38:19Z","timestamp":1514111899000},"page":"G129-G134","source":"Crossref","is-referenced-by-count":0,"title":["Vagovagal inhibition of motilin-induced phase III contractions by antral acidification in dog stomach"],"prefix":"10.1152","volume":"267","author":[{"given":"O.","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Gastrointestinal Research Laboratories, Gunma University, Maebashi,Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Matsunaga","sequence":"additional","affiliation":[{"name":"Gastrointestinal Research Laboratories, Gunma University, Maebashi,Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Haga","sequence":"additional","affiliation":[{"name":"Gastrointestinal Research Laboratories, Gunma University, Maebashi,Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Itoh","sequence":"additional","affiliation":[{"name":"Gastrointestinal Research Laboratories, Gunma University, Maebashi,Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpgi.1994.267.1.G129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T00:10:15Z","timestamp":1567987815000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpgi.1994.267.1.G129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1994,7,1]]}},"alternative-id":["10.1152\/ajpgi.1994.267.1.G129"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.1994.267.1.g129","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,7,1]]}}}