{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T14:00:19Z","timestamp":1648735219435},"reference-count":0,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[1997,5,1]]},"abstract":"<jats:p> The beta 3-adrenoceptor (beta 3-AR) agonist SR-58611A inverted question markethyl-[(7s)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]5, 6,7,8-tetrahydronaphth-2-yl]oxyacetate hydrochloride inverted question mark stimulated somatostatin and gastrin releases in isolated rat gastric antral epithelial cells. Stimulation was a concentration-dependent process with 50% effective concentrations of 2.7 +\/- 1.1 and 3.8 +\/- 1.9 nM compared with 209 +\/- 71 and 230 +\/- 51 nM for isoproterenol, respectively. It was inhibited by selective beta-AR antagonists with the following rank order of potency: SR-59230A 3-(2-ethylphenoxy)1-[(1S)-1,2,3,4-tetrahydronaphth- 1-ylamino]-(2S)-2-propranol oxalate; beta 3-AR antagonist &gt; ICI-118551[erythro-(+\/-)-1-(7-methylindan-4-yloxy)-3- isopropylaminobutan-2-ol-hydrochloride; beta 2-AR antagonist &gt; CGP-20712A[(+\/-)-[2-(3-carbarmoyl-4-hydroxyphenoxy)-et hyl- amino]-3-[4 (1-methyl-4-trifluoromethyl-2-imidazolyl)-phenoxy]- 2-propranol; beta 1-AR antagonist]. Furthermore, specific binding of 125I-cyanopindolol to the isolated cells was demonstrated and was displaced by the beta-AR antagonists according to the same rank order of potency and with apparent dissociation constants consistent with the 50% inhibitory concentrations for SR-58611A-stimulated somatostatin and gastrin releases. In addition, the presence of beta 3-AR mRNA was detected by reverse transcriptase polymerase chain reaction. These findings provide the first evidence for a gastric beta 3-AR mediating catecholamine stimulation of gastrin and somatostatin releases from antral cells. <\/jats:p>","DOI":"10.1152\/ajpgi.1997.272.5.g1000","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T12:35:57Z","timestamp":1514118957000},"page":"G1000-G1006","source":"Crossref","is-referenced-by-count":2,"title":["Characterization of a beta 3-adrenoceptor stimulating gastrin and somatostatin secretions in rat antrum"],"prefix":"10.1152","volume":"272","author":[{"given":"S.","family":"Levasseur","sequence":"first","affiliation":[{"name":"Institut National de la Sante et de la Recherche Medicale Unite 10,Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Bado","sequence":"additional","affiliation":[{"name":"Institut National de la Sante et de la Recherche Medicale Unite 10,Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. P.","family":"Laigneau","sequence":"additional","affiliation":[{"name":"Institut National de la Sante et de la Recherche Medicale Unite 10,Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Moizo","sequence":"additional","affiliation":[{"name":"Institut National de la Sante et de la Recherche Medicale Unite 10,Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Reyl-Desmars","sequence":"additional","affiliation":[{"name":"Institut National de la Sante et de la Recherche Medicale Unite 10,Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Lewin","sequence":"additional","affiliation":[{"name":"Institut National de la Sante et de la Recherche Medicale Unite 10,Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpgi.1997.272.5.G1000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T00:32:23Z","timestamp":1567989143000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpgi.1997.272.5.G1000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1997,5,1]]}},"alternative-id":["10.1152\/ajpgi.1997.272.5.G1000"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.1997.272.5.g1000","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,5,1]]}}}