{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T19:54:20Z","timestamp":1722455660197},"reference-count":0,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[1997,5,1]]},"abstract":"<jats:p> Interleukin-4 contributes to expulsion of certain gastrointestinal parasites and causes intestinal mucosal mastocytosis. Because mast cell-derived mediators are spasmogenic, potentially causing parasitic expulsion, we investigated the effect of interleukin-4 on smooth muscle and the mast cell and mediator dependency of this effect. BALB\/c, mast cell-deficient W\/Wv mice, 5-lipoxygenase-efficient mice, and their littermate controls were injected with interleukin-4-anti-interleukin-4 antibody complexes that chronically increase serum interleukin-4 levels. Mid-small intestinal segments, hung longitudinally in organ baths, were stimulated electrically or by agonists. The cholinergic response to electrical field stimulation was significantly increased by interleukin-4 treatment in BALB\/c but not W\/Wv mice. The enhanced cholinergic contraction was not due to increased acetylcholine responsiveness but was dependent on leukotriene D4, since it was reversed by leukotriene D4 receptor antagonism, and not observed in 5-lipoxygenase knock-out mice. Leukotriene D4 responsiveness was unaffected by interleukin-4 treatment. We conclude that interleukin-4 amplifies cholinergic excitation through a mast cell and leukotriene D4-dependent mechanism. <\/jats:p>","DOI":"10.1152\/ajpgi.1997.272.5.g1135","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T12:35:57Z","timestamp":1514118957000},"page":"G1135-G1140","source":"Crossref","is-referenced-by-count":9,"title":["Interleukin-4 modulates cholinergic neural control of mouse small intestinal longitudinal muscle"],"prefix":"10.1152","volume":"272","author":[{"given":"J.","family":"Goldhill","sequence":"first","affiliation":[{"name":"Department of Medicine, Uniformed Services University of the HealthSciences, Bethesda, Maryland 20815, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. C.","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Medicine, Uniformed Services University of the HealthSciences, Bethesda, Maryland 20815, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Maliszewski","sequence":"additional","affiliation":[{"name":"Department of Medicine, Uniformed Services University of the HealthSciences, Bethesda, Maryland 20815, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"J. F.","family":"Urban","sequence":"additional","affiliation":[{"name":"Department of Medicine, Uniformed Services University of the HealthSciences, Bethesda, Maryland 20815, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. D.","family":"Funk","sequence":"additional","affiliation":[{"name":"Department of Medicine, Uniformed Services University of the HealthSciences, Bethesda, Maryland 20815, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. D.","family":"Finkelman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Uniformed Services University of the HealthSciences, Bethesda, Maryland 20815, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Shea-Donohue","sequence":"additional","affiliation":[{"name":"Department of Medicine, Uniformed Services University of the HealthSciences, Bethesda, Maryland 20815, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpgi.1997.272.5.G1135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T00:32:31Z","timestamp":1567989151000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpgi.1997.272.5.G1135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1997,5,1]]}},"alternative-id":["10.1152\/ajpgi.1997.272.5.G1135"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.1997.272.5.g1135","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,5,1]]}}}