{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T22:19:25Z","timestamp":1649024365938},"reference-count":0,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[1997,5,1]]},"abstract":"<jats:p> Neurons that contain substance P (SP) and thyrotropin-releasing hormone (TRH) in medullary midline raphe nuclei project to the dorsal vagal complex (DVC). The modulatory role of SP on basal gastric acid secretion (GAS) and TRH on DVC-induced stimulation of GAS was studied in urethan-anesthetized rats. The stable SP agonist, DiMe-C7 ([pGlu5, MePhe8, MeGly9]SP5-11, 50 and 100 pmol), injected unilaterally into the DVC reduced the GAS response (47 +\/- 12 mumol\/60 min) to coinjected TRH analog, RX 77368 (25 pmol), by 53% and 85%, respectively, whereas DiMe-C7 (100 pmol) alone had no effect on basal and pentagastrin-stimulated GAS. DiMe-C7 (100 pmol\/site) inhibited the GAS response to kainic acid injected into the raphe pallidus (Rpa) when it was injected bilaterally into the DVC but not the hypoglossal nuclei. The SP nourokinin-1-receptor antagonist, CP-96,345, injected bilaterally into the DVC (1 nmol\/ site) increased basal GAS (33 +\/- 8 mumol\/90 min) and potentiated the GAS response to kainic acid injected into the Rpa by 40%. These results suggest that SP acts on neurokinin-1 receptors in the DVC to reduce medullary TRH-induced stimulation of GAS in rats. <\/jats:p>","DOI":"10.1152\/ajpgi.1997.272.5.g987","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T12:35:57Z","timestamp":1514118957000},"page":"G987-G993","source":"Crossref","is-referenced-by-count":0,"title":["Substance P in the dorsal vagal complex inhibits medullary TRH-induced gastric acid secretion in rats"],"prefix":"10.1152","volume":"272","author":[{"given":"H.","family":"Yang","sequence":"first","affiliation":[{"name":"CURE: Digestive Diseases Research Center, Department of VeteransAffairs Medical Center West Los Angeles, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Tache","sequence":"additional","affiliation":[{"name":"CURE: Digestive Diseases Research Center, Department of VeteransAffairs Medical Center West Los Angeles, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpgi.1997.272.5.G987","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T00:32:16Z","timestamp":1567989136000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpgi.1997.272.5.G987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1997,5,1]]}},"alternative-id":["10.1152\/ajpgi.1997.272.5.G987"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.1997.272.5.g987","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,5,1]]}}}