{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T12:02:49Z","timestamp":1748606569980},"reference-count":35,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[1998,1,1]]},"abstract":"<jats:p> Erythromycin overcomes postvagotomy gastroparesia in patients without a distal stomach and functional pylorus. We investigate the role of the vagus in gastric emptying increased by erythromycin, using a model that preserves the physiology of the distal stomach and pylorus. The effects of erythromycin lactobionate (10 mg\/kg) on transpyloric flow pattern and pyloric resistance were evaluated during repetitive bilateral vagal cooling in anesthetized pigs. Vagal cooling during erythromycin infusion produced a marked decreased of pyloric outflow (23 \u00b1 1.1 vs. 50 \u00b1 2.6 ml\/min) related to a reduced stroke volume of the flow pulses (7.8 \u00b1 3.31 vs. 14.1 \u00b1 2.44 ml). The amplitude and frequency of gastric and duodenal pressure events were unchanged or slightly reduced during vagal cooling. The smaller stroke volume of flow pulse was the consequence of increased pyloric resistance (6.2 \u00b1 1.98 vs. 2.3 \u00b1 0.21 mmHg \u22c5 ml<jats:sup>\u22121<\/jats:sup> \u22c5 s), which is associated with changes in the temporal relationship between a pyloric pressure event and flow pulse. In conclusion, erythromycin activity on the pylorus requires the integrity of vagal pathways. Enhancement of gastric outflow by erythromycin is also modulated by the vagus, since pyloric resistance was able to overcome increased gastric motility. <\/jats:p>","DOI":"10.1152\/ajpgi.1998.274.1.g80","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T09:21:47Z","timestamp":1514107307000},"page":"G80-G86","source":"Crossref","is-referenced-by-count":3,"title":["Erythromycin gastrokinetic activity  is partially vagally mediated"],"prefix":"10.1152","volume":"274","author":[{"given":"C.","family":"Mathis","sequence":"first","affiliation":[{"name":"Unit\u00e9 de Contr\u00f4le des Flux Digestifs et M\u00e9tabolisme Prot\u00e9ique, Station de Recherches Porcines, Institut National de la Recherche Agronomique, Saint-Gilles 35590, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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