{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T02:42:37Z","timestamp":1785552157852,"version":"3.56.0"},"reference-count":31,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[1998,11,1]]},"abstract":"<jats:p>The effects of the nitric oxide donor nitroglycerin on gastric emptying and antropyloroduodenal motility were evaluated in nine healthy male subjects (ages 19\u201336 yr). Antropyloroduodenal pressures were recorded with a manometric assembly that had nine side holes spanning the antrum and proximal duodenum and a pyloric sleeve sensor; gastric emptying was quantified scintigraphically. In each subject, the emptying of 300 ml of 25% glucose labeled with<jats:sup>99m<\/jats:sup>Tc was assessed on two separate days during intravenous infusion of either nitroglycerin (5 \u03bcg\/min in 5% dextrose) or 5% dextrose (control). Studies were performed with the subject in the supine position; blood pressure and heart rate were monitored. Nitroglycerin had no significant effect on blood pressure or heart rate. Nitroglycerin slowed gastric emptying ( P &lt; 0.02), and this was associated with greater retention of the drink in the proximal stomach ( P &lt; 0.05). In both nitroglycerin and control studies, ingestion of the drink was associated with an increase in the number of isolated pyloric pressure waves ( P &lt; 0.05) and antral pressure wave sequences ( P &lt; 0.05). Nitroglycerin reduced the number of isolated pyloric pressure waves ( P &lt; 0.05), basal pyloric pressure ( P &lt; 0.05), and the number of antral pressure wave sequences ( P &lt; 0.05), but not the total number of antral pressure waves. The rate of gastric emptying and the number of isolated pyloric pressure waves were inversely related during control ( P = 0.03) and nitroglycerin ( P &lt; 0.05) infusions. We conclude that in normal subjects, 1) gastric emptying of 300 ml of 25% glucose is inversely related to the frequency of phasic pyloric pressure waves, and 2) nitroglycerin in a dose of 5 \u03bcg\/min inhibits pyloric motility, alters the organization but not the number of antral pressure waves, and slows gastric emptying and intragastric distribution of 25% glucose.<\/jats:p>","DOI":"10.1152\/ajpgi.1998.275.5.g1173","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T09:27:41Z","timestamp":1514107661000},"page":"G1173-G1178","source":"Crossref","is-referenced-by-count":18,"title":["Effects of nitroglycerin on liquid gastric emptying and antropyloroduodenal motility"],"prefix":"10.1152","volume":"275","author":[{"given":"W.-M.","family":"Sun","sequence":"first","affiliation":[{"name":"Departments of Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Doran","sequence":"additional","affiliation":[{"name":"Departments of Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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