{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T17:50:20Z","timestamp":1718041820275},"reference-count":29,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[1999,1,1]]},"abstract":"<jats:p>Insulin-like growth factor I (IGF-I) bioavailability is reduced in liver cirrhosis, a condition frequently associated with malnutrition. We have analyzed in vivo absorption ofd-galactose by jejunal loops in rats with CCl<jats:sub>4<\/jats:sub>-induced liver cirrhosis and the influence of IGF-I on intestinal sugar transport in this disease. Two different study protocols were followed. In protocol 1, healthy control rats or cirrhotic rats received saline or IGF-I (2 \u03bcg \u22c5 100 g body wt<jats:sup>\u22121<\/jats:sup>\u22c5 day<jats:sup>\u22121<\/jats:sup>) for 2 wk. In protocol 2, control and cirrhotic rats received saline or IGF-I as a bolus injection of 1 \u03bcg\/100 g body wt followed by continuous infusion of the same dose for 100 min. In vivod-galactose absorption was reduced in cirrhotic rats compared with healthy controls. IGF-I, as both a chronic ( protocol 1) and acute treatment ( protocol 2), was able to improve sugar transport in cirrhotic rats but had no effect on sugar absorption in healthy rats. A significant elongation of enterocyte microvilli was observed in cirrhotic animals; this alteration was totally or partially corrected by chronic or acute IGF-I administration. Our results show that in vivo jejunal sugar transport and microvilli structure are altered in liver cirrhosis and that IGF-I, among other effects, may correct these changes by modulating cytoskeletal organization in enterocytes.<\/jats:p>","DOI":"10.1152\/ajpgi.1999.276.1.g37","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T09:57:52Z","timestamp":1514109472000},"page":"G37-G42","source":"Crossref","is-referenced-by-count":10,"title":["Effect of insulin-like growth factor I on in vivo intestinal absorption of<scp>d<\/scp>-galactose in cirrhotic rats"],"prefix":"10.1152","volume":"276","author":[{"given":"Inma","family":"Castilla-Cort\u00e1zar","sequence":"first","affiliation":[{"name":"Departments of Human Physiology and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Picardi","sequence":"additional","affiliation":[{"name":"Departments of Human Physiology and"},{"name":"Department of Internal Medicine, Biomedical Campus, Libero Istituto Universitario, 00155 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"Tosar","sequence":"additional","affiliation":[{"name":"Departments of Human Physiology and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Ainz\u00faa","sequence":"additional","affiliation":[{"name":"Departments of Human Physiology and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Urdaneta","sequence":"additional","affiliation":[{"name":"Departments of Human Physiology and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Departments of Human Physiology and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Pascual","sequence":"additional","affiliation":[{"name":"Departments of Human Physiology and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Quiroga","sequence":"additional","affiliation":[{"name":"Internal Medicine, Liver Unit, School of Medicine, University of Navarra, 31080 Pamplona, Spain; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Prieto","sequence":"additional","affiliation":[{"name":"Internal Medicine, Liver Unit, School of Medicine, University of Navarra, 31080 Pamplona, Spain; and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1159\/000129038"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v113.pm9352873"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v113.pm9322513"},{"key":"B4","first-page":"283","volume":"62","author":"Chatamra K.","year":"1981","journal-title":"Br. 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