{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:45:45Z","timestamp":1787017545757,"version":"build-2736575974"},"reference-count":24,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[1999,7,1]]},"abstract":"<jats:p>\n                    The effects of arginine vasopressin (AVP) on pancreatic ductal secretion were studied in guinea pigs. In the isolated vascularly perfused pancreas, AVP reduced secretin-stimulated fluid secretion and increased the vascular resistance when the perfusion rate was held constant. In the isolated interlobular duct segments, AVP inhibited secretin-stimulated fluid secretion, indicating the direct inhibitory action of AVP on the duct cells. AVP affected neither the basal nor the secretin-induced cAMP productions, suggesting that AVP inhibits the fluid secretion at a point distal to the production of cAMP. AVP increased intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    concentration ([Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ]\n                    <jats:sub>i<\/jats:sub>\n                    ) in the absence of extracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    . When [Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ]\n                    <jats:sub>i<\/jats:sub>\n                    was elevated by the application of thapsigargin, AVP caused a rapid decrease in [Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ]\n                    <jats:sub>i<\/jats:sub>\n                    . AVP seems to activate both Ca\n                    <jats:sup>2+<\/jats:sup>\n                    release from intracellular stores and Ca\n                    <jats:sup>2+<\/jats:sup>\n                    efflux across the plasma membrane, but its relation to the inhibition of fluid secretion remains to be clarified. It is concluded that AVP directly inhibits secretin-stimulated ductal fluid secretion in the guinea pig pancreas.\n                  <\/jats:p>","DOI":"10.1152\/ajpgi.1999.277.1.g48","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T05:04:59Z","timestamp":1514091899000},"page":"G48-G54","source":"Crossref","is-referenced-by-count":6,"title":["Arginine vasopressin inhibits fluid secretion in guinea pig pancreatic duct cells"],"prefix":"10.1152","volume":"277","author":[{"given":"S. B. 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