{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:15:33Z","timestamp":1791972933077,"version":"4.3.4"},"reference-count":21,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2000,4,1]]},"abstract":"<jats:p> The relative contributions to gastric emptying from common cavity antroduodenal pressure difference (\u201cpressure pump\u201d) vs. propagating high-pressure waves in the distal antrum (\u201cperistaltic pump\u201d) were analyzed in humans by high-resolution manometry concurrently with time-resolved three-dimensional magnetic resonance imaging during intraduodenal nutrient infusion at 2 kcal\/min. Gastric volume, space-time pressure, and contraction wave histories in the antropyloroduodenal region were measured in seven healthy subjects. The subjects fell into two distinct groups with an order of magnitude difference in levels of antral pressure activity. However, there was no significant difference in average rate of gastric emptying between the two groups. Antral pressure history was separated into \u201cpropagating high-pressure events\u201d (HPE), \u201cnonpropagating HPEs,\u201d and \u201cquiescent periods.\u201d Quiescent periods dominated, and average pressure during quiescent periods remained unchanged with decreasing gastric volume, suggesting that common cavity pressure levels were maintained by increasing wall muscle tone with decreasing volume. When propagating HPEs moved to within 2\u20133 cm of the pylorus, pyloric resistance was found statistically to increase with decreasing distance between peristaltic waves and the pylorus. We conclude that transpyloric flow tends to be blocked when antral contraction waves are within a \u201czone of influence\u201d proximal to the pylorus, suggesting physiological coordination between pyloric and antral contractile activity. We further conclude that gastric emptying of nutrient liquids is primarily through the \u201cpressure pump\u201d mechanism controlled by pyloric opening during periods of relative quiescence in antral contractile wave activity. <\/jats:p>","DOI":"10.1152\/ajpgi.2000.278.4.g604","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T15:10:01Z","timestamp":1514128201000},"page":"G604-G616","source":"Crossref","is-referenced-by-count":127,"title":["Relative contributions of \u201cpressure pump\u201d and \u201cperistaltic pump\u201d to gastric emptying"],"prefix":"10.1152","volume":"278","author":[{"given":"K.","family":"Indireshkumar","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering, Pennsylvania State University, University Park, Pennsylvania 16802;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James G.","family":"Brasseur","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Pennsylvania State University, University Park, Pennsylvania 16802;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henryk","family":"Faas","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Medical Informatics, Swiss Federal Institute of Technology, Zurich;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey S.","family":"Hebbard","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University Hospital, Zurich, Switzerland; 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