{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:58:36Z","timestamp":1791187116256,"version":"4.1.0"},"reference-count":29,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2000,6,1]]},"abstract":"<jats:p>The amylin analog pramlintide delays gastric emptying in type I diabetics. The effects of multiple doses of pramlintide and the mechanism of action in non-amylin-deficient humans are unknown. We investigated the effects of pramlintide on gastrointestinal and colonic transit and on the plasma pancreatic polypeptide response to the meal in a parallel-group dose-response study with subjects randomized to placebo, or 30 or 60 \u03bcg (tid, sc) of pramlintide. Pramlintide delayed gastric emptying [half-time ( t<jats:sub>\u00bd<\/jats:sub>): 112 min (SE 8.7 min), 169 min (SE 12 min), or 177 min (SE 25 min) after placebo or 30- or 60-\u03bcg pramlintide treatment, respectively; P = 0.033]. Pramlintide did not significantly affect small bowel or colonic transit. Pancreatic polypeptide concentrations in the first postprandial hour were lower with pramlintide than with placebo ( P &lt; 0.01 for drug effect). An inverse correlation was observed between mean pancreatic polypeptide concentrations in the first postprandial hour and gastric emptying t<jats:sub>\u00bd<\/jats:sub>[Spearman correlation coefficient ( R<jats:sub>s<\/jats:sub>) = 0.48; P = 0.044]. Pramlintide at 30 and 60 \u03bcg delays gastric emptying in healthy humans without affecting small bowel or colonic transit. Vagal inhibition is a potential mechanism of the effects of pramlintide on gastric emptying.<\/jats:p>","DOI":"10.1152\/ajpgi.2000.278.6.g946","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T15:07:31Z","timestamp":1514128051000},"page":"G946-G951","source":"Crossref","is-referenced-by-count":116,"title":["Pramlintide, an amylin analog, selectively delays gastric emptying: potential role of vagal inhibition"],"prefix":"10.1152","volume":"278","author":[{"given":"Melvin","family":"Samsom","sequence":"first","affiliation":[{"name":"Gastroenterology Research Unit,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence A.","family":"Szarka","sequence":"additional","affiliation":[{"name":"Gastroenterology Research Unit,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Camilleri","sequence":"additional","affiliation":[{"name":"Gastroenterology Research 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