{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T16:58:59Z","timestamp":1697043539787},"reference-count":41,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2000,9,1]]},"abstract":"<jats:p> The site of action of peripheral peptide YY (PYY)-induced inhibition of vagally stimulated gastric acid secretion was studied using immunoneutralization with PYY antibody in urethan-anesthetized rats. Gastric acid secretion (59 \u00b1 7 \u03bcmol\/90 min) stimulated by intracisternal injection of the stable thyrotropin-releasing hormone (TRH) analog RX-77368 (14 pmol\/rat) was dose-dependently inhibited by 52%, 69%, and 83% by intravenous infusion of 0.25, 0.5, and 1.0 nmol \u00b7 kg<jats:sup>\u22121<\/jats:sup> \u00b7 h<jats:sup>\u22121<\/jats:sup> PYY, respectively. PYY or PYY<jats:sub>3\u201336<\/jats:sub> (2.4 pmol\/rat) injected intracisternally also inhibited the acid response to intracisternal RX-77368 by 73% and 80%, respectively. Intravenous pretreatment with PYY antibody (4.5 mg\/rat), which shows a 35% cross-reaction with PYY<jats:sub>3\u201336<\/jats:sub> by RIA, completely prevented the inhibitory effect of intravenously infused PYY (1 nmol \u00b7 kg<jats:sup>\u22121<\/jats:sup> \u00b7 h<jats:sup>\u22121<\/jats:sup>). When injected intracisternally, the PYY antibody (280 \u03bcg\/rat) reversed intracisternal PYY (2.4 pmol)- and intravenous PYY (1 nmol \u00b7 kg<jats:sup>\u22121<\/jats:sup> \u00b7 h<jats:sup>\u22121<\/jats:sup>)-induced inhibition of acid response to intracisternal RX-77368 by 64% and 93.5%, respectively. These results provide supporting evidence that peripheral PYY inhibits central vagal stimulation of gastric acid secretion through an action in the brain. <\/jats:p>","DOI":"10.1152\/ajpgi.2000.279.3.g575","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T15:23:14Z","timestamp":1514128994000},"page":"G575-G581","source":"Crossref","is-referenced-by-count":13,"title":["Peripheral PYY inhibits intracisternal TRH-induced gastric acid secretion by acting in the brain"],"prefix":"10.1152","volume":"279","author":[{"given":"Hong","family":"Yang","sequence":"first","affiliation":[{"name":"CURE: Digestive Diseases Research Center, Veterans Affairs Greater Los Angeles Healthcare System, and Digestive Diseases Division, Department of Medicine and Brain Research Institute, School of Medicine, University of California, Los Angeles, California 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