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Both p21<jats:sup>WAF1\/CIP1<\/jats:sup>and Bax were also upregulated in duct-ligated lobes. After PDL in p53(+\/+) mice, acinar cells underwent widespread apoptosis, while duct-like epithelium underwent proliferative expansion. In the absence of p53, upregulation of p53 target genes and acinar cell apoptosis did not occur. The absence of acinar cell apoptosis in p53(\u2212\/\u2212) mice also eliminated the proliferative response to duct ligation. These data demonstrate that PDL-induced acinar cell apoptosis is a p53-dependent event and suggest a direct link between acinar cell apoptosis and proliferation of duct-like epithelium in duct-ligated pancreas.<\/jats:p>","DOI":"10.1152\/ajpgi.2000.279.4.g827","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T15:26:36Z","timestamp":1514129196000},"page":"G827-G836","source":"Crossref","is-referenced-by-count":48,"title":["p53-Dependent acinar cell apoptosis triggers epithelial proliferation in duct-ligated murine pancreas"],"prefix":"10.1152","volume":"279","author":[{"given":"Charles R.","family":"Scoggins","sequence":"first","affiliation":[{"name":"Departments of Surgery and Cell Biology, The Vanderbilt-Ingram Cancer Center and Nashville Veterans Affairs Medical Center, Vanderbilt University, Nashville, Tennessee 37232-2736"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid 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