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Women showed less activity ( P &lt; 0.05) in the transverse\/descending colon than men. The transverse\/descending colon showed more ( P &lt; 0.05) activity than the rectosigmoid colon. Seven patterns were recognized; predominantly, they were simultaneous, propagated, or periodic bursts of 3-cycles\/min (cpm) waves. A specialized propagating pressure wave with a high amplitude (&gt;105 mmHg) and a prolonged duration (&gt;14 s) occurred in all subjects (mean 10\/day), mostly after waking, after meals, or with defecation. A 3-cpm motor activity was seen in the rectosigmoid region predominantly at night. The colon exhibits a wide spectrum of pressure activity around the clock, with gender and regional differences and circadian rhythm. 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