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Despite significant elevations in mean peak serum tumor necrosis factor-\u03b1 (TNF-\u03b1) concentrations (90.9 \u00b1 16.2 ng\/ml), there was no effect on mean rates of bile flow or biliary ICG clearance after administration of 100 \u03bcg\/kg endotoxin at 6 or 24 h. Significant differences from mean baseline rates of bile flow and biliary ICG excretion did occur after administration of 1,000 \u03bcg\/kg endotoxin (mean peak TNF-\u03b1 129.6 \u00b1 24.4 ng\/ml). Furthermore, when rats were treated with up to 16 \u03bcg\/kg of recombinant TNF-\u03b1, there was no change in mean rates of bile flow or ICG biliary clearance compared with baseline values. These data suggest that the complex regulation of biliary excretion is not mediated solely by TNF-\u03b1. <\/jats:p>","DOI":"10.1152\/ajpgi.2001.280.5.g858","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T15:41:20Z","timestamp":1514130080000},"page":"G858-G865","source":"Crossref","is-referenced-by-count":7,"title":["Endotoxin-induced reduction in biliary indocyanine green excretion rate in a chronically catheterized rat model"],"prefix":"10.1152","volume":"280","author":[{"given":"David W. 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