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Fos-immunoreactive cells were rare in controls (\u223c1 cell\/ganglion), whereas intracisternal RX-77368 (50 ng) increased the number to 24.8 \u00b1 1.8 and 26.8 \u00b1 2.2 cells\/ganglion in the corpus and antrum, respectively. Hexamethonium (20 mg\/kg sc) prevented Fos expression by 90%, whereas atropine (2 mg\/kg sc) had no effect. The neuronal marker protein gene product 9.5 and the glial markers S-100 and glial fibrillary acidic proteins showed that RX-77368 induced Fos in both myenteric neurons and glia. Vesicular ACh transporter and calretinin were detected around the activated myenteric neurons. These results indicated that central vagal efferent stimulation by intracisternal RX-77368 activates gastric myenteric neurons as well as glial cells mainly through nicotinic ACh receptors in conscious rats.<\/jats:p>","DOI":"10.1152\/ajpgi.2001.280.5.g979","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T15:41:20Z","timestamp":1514130080000},"page":"G979-G991","source":"Crossref","is-referenced-by-count":36,"title":["Intracisternal TRH analog induces Fos expression in gastric myenteric neurons and glia in conscious rats"],"prefix":"10.1152","volume":"280","author":[{"given":"Marcel","family":"Miampamba","sequence":"first","affiliation":[{"name":"CURE: Digestive Diseases Research Center, Veterans Affairs Greater Los Angeles Healthcare System, and Department of Medicine and Brain Research Institute, University of California, Los Angeles, California 90073; 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