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Recent advances in the development of in vitro and in vivo models of disease, new genetic approaches, the identification of key E. histolytica virulence factors, and the recognition of crucial elements of the host response to infection have led to significant insights into the pathogenesis of amebic infection. E. histolytica virulence factors include 1) a surface galactose binding lectin that mediates E. histolyticabinding to host cells and may contribute to amebic resistance to complement, 2) amebapores, small peptides capable of lysing cells, which may play a role in killing intestinal epithelial cells, hepatocytes, and host defense cells, and 3) a family of secreted cysteine proteinases that play a key role in E. histolytica tissue invasion, evasion of host defenses, and parasite induction of gut inflammation. Amebae can both lyse host cells and induce their suicide through programmed cell death. The host response is also an important factor in the outcome of infection, and neutrophils may play a key role in contributing to the tissue damage seen in amebiasis and in controlling amebic infection.<\/jats:p>","DOI":"10.1152\/ajpgi.2001.280.6.g1049","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T15:38:26Z","timestamp":1514129906000},"page":"G1049-G1054","source":"Crossref","is-referenced-by-count":44,"title":["VI.<i>Entamoeba histolytica<\/i>: parasite-host interactions"],"prefix":"10.1152","volume":"280","author":[{"suffix":"Jr.","given":"Samuel L.","family":"Stanley","sequence":"first","affiliation":[{"name":"Departments of Medicine and Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon L.","family":"Reed","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Medicine, University of California, San 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