{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T09:40:06Z","timestamp":1774777206465,"version":"3.50.1"},"reference-count":34,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2001,6,1]]},"abstract":"<jats:p>We investigated the role of nuclear factor-\u03baB (NF-\u03baB) in gastric ulcer healing in rats. NF-\u03baB was activated in ulcerated tissue but not in normal mucosa, and the level of the activation was decreased with ulcer healing. NF-\u03baB activation was observed in fibroblasts, monocytes\/macrophages, and neutrophils. Treatment of gastric fibroblasts, isolated from the ulcer base, with interleukin-1\u03b2 activated NF-\u03baB and the subsequently induced cyclooxygenase-2 and cytokine-induced neutrophil chemoattractant-1 (CINC-1) mRNA expression. Inhibition of activated NF-\u03baB action resulted in suppression of both their mRNA expression and increases in PGE<jats:sub>2<\/jats:sub>and CINC-1 levels induced by interleukin-1\u03b2. Persistent prevention of NF-\u03baB activation caused an impairment of ulcer healing in rats. Gene expression of interleukin-1\u03b2, CINC-1, cyclooxygenase-2, and inducible nitric oxide synthase in ulcerated tissue had been inhibited before the delay in ulcer healing became manifest. The increased levels of cyclooxygenase-2 protein and PGE<jats:sub>2<\/jats:sub>production were also reduced. These results demonstrate that NF-\u03baB, activated in ulcerated tissue, might upregulate the expression of healing-promoting factors responsible for gastric ulcer healing in rats.<\/jats:p>","DOI":"10.1152\/ajpgi.2001.280.6.g1296","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T15:38:26Z","timestamp":1514129906000},"page":"G1296-G1304","source":"Crossref","is-referenced-by-count":29,"title":["Role of nuclear factor-\u03baB in gastric ulcer healing in rats"],"prefix":"10.1152","volume":"280","author":[{"given":"Satoru","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Applied Pharmacology and"},{"name":"Department of Biopharmaceutics, Kyoto Pharmaceutical University, Kyoto 607-8414, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Biopharmaceutics, Kyoto Pharmaceutical University, Kyoto 607-8414, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Biopharmaceutics, Kyoto Pharmaceutical University, Kyoto 607-8414, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02093610"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.14.1.649"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.8436"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)90126-J"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1995.268.6.F1224"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90021-2"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018815802500"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v113.pm9322504"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90564-2"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(93)90997-V"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90833-7"},{"key":"B12","first-page":"658","volume":"55","author":"Liu SF","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v112.pm9024292"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/nm0897-894"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/BF02220461"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(91)90405-Z"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.49.31496"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1995.268.2.G276"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1084\/jem.175.5.1181"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1995.tb20701.x"},{"key":"B21","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/S0022-3565(24)37734-1","volume":"286","author":"Shigeta J","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cb.10.110194.002201"},{"key":"B23","first-page":"515","volume":"49","author":"Suzuki N","year":"1998","journal-title":"J Physiol Pharmacol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119080"},{"key":"B25","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/S0022-3565(24)35149-3","volume":"291","author":"Takahashi S","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1998.275.5.G1137"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018867630686"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.9.4350"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(05)80075-0"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15234.x"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1993.tb17920.x"},{"key":"B32","first-page":"971","volume":"150","author":"Watanabe T","year":"1997","journal-title":"Am J Pathol"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026683824850"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1177\/002215549804600402"}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpgi.2001.280.6.G1296","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T05:14:10Z","timestamp":1751174050000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpgi.2001.280.6.G1296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,6,1]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2001,6,1]]}},"alternative-id":["10.1152\/ajpgi.2001.280.6.G1296"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.2001.280.6.g1296","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,6,1]]}}}