{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:36:00Z","timestamp":1790678160343,"version":"4.1.0"},"reference-count":31,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2001,8,1]]},"abstract":"<jats:p> Our objectives were to characterize colonic viscoelastic properties of the human descending colon by assessing pressure-volume (P-V) relationships during barostatic balloon distension. In 16 healthy subjects, a balloon was inflated to 44 mmHg and then deflated to 0 mmHg in 4-mmHg steps at 10, 30, and 60 ml\/min, allowing volume fluctuations to stabilize at each pressure increment. Thereafter, these \u201cquasi-static\u201d P-V curves were compared with \u201cdynamic\u201d distensions to 300 ml, at 1 and 10 ml\/s, before and after intravenous atropine in another five subjects. During quasi-static curves, balloon volume stabilized at each pressure increment. Quasi-static P-V curves were reproducible within individuals and approximated to a power exponential function and revealed hysteresis, indicative of viscoelasticity. Body mass index influenced quasi-static P-V curves during inflation but not during deflation. The colon was less compliant during dynamic distensions at 10 ml\/s than during quasi-static distensions. Atropine increased quasi-static compliance and attenuated differences between quasi-static and rapid distensions. We conclude that colonic viscoelastic properties can be assessed by quasi-static P-V curves. Rapid colonic distension activated neural reflexes, thereby reducing colonic compliance compared with quasi-static distensions. <\/jats:p>","DOI":"10.1152\/ajpgi.2001.281.2.g459","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T15:33:10Z","timestamp":1514129590000},"page":"G459-G466","source":"Crossref","is-referenced-by-count":51,"title":["Viscoelastic properties of the human colon"],"prefix":"10.1152","volume":"281","author":[{"given":"Adil E.","family":"Bharucha","sequence":"first","affiliation":[{"name":"Gastroenterology Research Unit and Enteric Neurosciences Program,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf D.","family":"Hubmayr","sequence":"additional","affiliation":[{"name":"Thoracic Diseases Research Unit, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene J.","family":"Ferber","sequence":"additional","affiliation":[{"name":"Gastroenterology Research Unit and Enteric Neurosciences Program,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan R.","family":"Zinsmeister","sequence":"additional","affiliation":[{"name":"Section of Biostatistics, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1994.267.2.G166"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.30.4.496"},{"key":"B3","first-page":"134","volume":"48","author":"Bates JH.","year":"1993","journal-title":"Monaldi Arch Chest Dis"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.5.667"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1997.273.5.G997"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1998.00305.x"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)85511-0"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1998.00375.x"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1136\/gut.37.2.264"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1993.74.3.1387"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.156.6.9611016"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1989.67.6.2408"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1114\/1.109"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.1996.tb00267.x"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1998.274.3.G584"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1136\/gut.31.9.1062"},{"key":"B18","first-page":"477","volume":"51","author":"Loring SH","year":"1981","journal-title":"J Appl Physiol Respir Environ Exercise Physiol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00757.x"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/BF02765589"},{"key":"B22","first-page":"171","volume":"7","author":"Pidaparti RM","year":"1997","journal-title":"Biomed Mater Eng"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1993.265.4.G742"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)90255-1"},{"key":"B27","first-page":"883","volume":"163","author":"Shafik A","year":"1997","journal-title":"Eur J Surg"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1997.89104000.x"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(90)90620-G"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)62169-7"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)83446-X"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1136\/gut.27.3.288"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018885028501"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70099-X"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpgi.2001.281.2.G459","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T01:12:05Z","timestamp":1567991525000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpgi.2001.281.2.G459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,8,1]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,8,1]]}},"alternative-id":["10.1152\/ajpgi.2001.281.2.G459"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.2001.281.2.g459","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,8,1]]}}}