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These examples review two of the most potent modulatory processes at work within the dorsal vagal complex, which have dramatic effects on gastrointestinal function. The reader should be mindful of the fact that many more different inputs from other central nervous system (CNS) loci or circulating humoral factors add to this complex mix of modulatory inputs. It is likely that similar long-term modulations of synaptic transmission occur with other neurotransmitters and may represent an important mechanism for the integration and regulation of neuronal behavior. Of course, this fact strongly militates against the success of any single drug or approach in the treatment of motility disorders having a CNS component.<\/jats:p>","DOI":"10.1152\/ajpgi.2001.281.3.g595","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T16:02:59Z","timestamp":1514131379000},"page":"G595-G601","source":"Crossref","is-referenced-by-count":42,"title":["V. 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