{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T18:54:05Z","timestamp":1781808845392,"version":"3.54.5"},"reference-count":63,"publisher":"American Physiological Society","issue":"1","funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL142807"],"award-info":[{"award-number":["HL142807"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:p>We identified cytoglobin as an important globin in cardiac pathophysiology. Genetic deletion of cytoglobin led to exacerbation of angiotensin II-mediated cardiac hypertrophy in the absence of any effect on systemic blood pressure. Cytoglobin is expressed in cardiac fibroblasts and pericytes and is required for cardiac fibroblast activation. The present study reveals for the first time a role for cytoglobin in regulating angiotensin II signaling.<\/jats:p>","DOI":"10.1152\/ajpheart.00008.2026","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T12:02:42Z","timestamp":1780315362000},"page":"H100-H114","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic deletion of cytoglobin exacerbates cardiac hypertrophy and inhibits cardiac fibroblast activation independent of changes in blood pressure"],"prefix":"10.1152","volume":"331","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4328-2006","authenticated-orcid":false,"given":"Le Gia Cat","family":"Pham","sequence":"first","affiliation":[{"name":"Albany Medical College","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurrim","family":"Gilliard","sequence":"additional","affiliation":[{"name":"Albany Medical College","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances","family":"Jourd\u2019heuil","sequence":"additional","affiliation":[{"name":"Albany Medical College","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarahann","family":"Mistretta","sequence":"additional","affiliation":[{"name":"Albany Medical College","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Albany Medical College","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8554-3239","authenticated-orcid":false,"given":"Harold A.","family":"Singer","sequence":"additional","affiliation":[{"name":"Albany Medical College","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6555-5061","authenticated-orcid":false,"given":"David","family":"Jourd\u2019heuil","sequence":"additional","affiliation":[{"name":"Albany Medical College","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/327524a0"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.33.4.937"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200305000-00025"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1100-z"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/377239a0"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.23.13176"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/416337a"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1161\/hy02t2.102796"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1998.00947.x"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1161\/hy0102.100540"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M808231200"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.117.309410"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102838"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2025.103633"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14807"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0363com"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014400"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.80479"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.045115"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/s44161-022-00028-6"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.2.339"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.5.15.1835945"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.55.030193.000415"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.12r04cp"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M310540200"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700013"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M809572200"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000182903.16652.d7"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2014.01.011"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1002\/2211-5463.13021"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.300507"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.06.015"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2017.05.102"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/ng1180"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.320324"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03549-5"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/75556"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/iyad031"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btn615"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00256.2016"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1407097111"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-82941-7"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2013.09.015"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(00)81573-1"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.100.11.1223"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.30.6.1397"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62289-4"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608799103"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000126924.23467.A3"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.73.3.413"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64454-9"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.10.002"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1172\/JCI14190"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.0000043825.01705.1b"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2014.12.017"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.03.051"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M102630200"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.5971.1"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2020.10.321"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-024-01062-6"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.315322"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2005"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00008.2026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T18:38:16Z","timestamp":1781807896000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00008.2026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":63,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,7,1]]}},"alternative-id":["10.1152\/ajpheart.00008.2026"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00008.2026","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,1]]},"assertion":[{"value":"2026-01-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-24","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}