{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T04:29:37Z","timestamp":1784953777256,"version":"3.55.0"},"reference-count":43,"publisher":"American Physiological Society","issue":"1","funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL169202"],"award-info":[{"award-number":["HL169202"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["CDA857268"],"award-info":[{"award-number":["CDA857268"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:p>This study identifies progranulin (PGRN) as a key regulator of premature vascular dysfunction. Using human and mouse arteries and integrated multi-omics analyses, we show that PGRN deficiency induces early vascular senescence, mitochondrial dysfunction, epigenetic remodeling, and fibrosis. Senolytic treatment uncovers divergent roles of endothelial versus smooth muscle cell senescence in vascular function, highlighting PGRN as an important modulator of vascular homeostasis during aging.<\/jats:p>","DOI":"10.1152\/ajpheart.00012.2026","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:23:55Z","timestamp":1780489435000},"page":"H260-H275","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Progranulin deficiency induces premature vascular senescence and dysfunction"],"prefix":"10.1152","volume":"331","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9548-6338","authenticated-orcid":false,"given":"Renata de Azevedo Melo","family":"Luvizotto","sequence":"first","affiliation":[{"name":"University of South Alabama","place":["United States"]},{"name":"Federal University of Mato Grosso","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6118-2133","authenticated-orcid":false,"given":"Andr\u00e9 F.","family":"Nascimento","sequence":"additional","affiliation":[{"name":"University of South Alabama","place":["United States"]},{"name":"Federal University of Mato Grosso","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo F.","family":"Pimenta","sequence":"additional","affiliation":[{"name":"University of South Alabama","place":["United States"]},{"name":"University of Sao Paulo","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael M.","family":"de Costa","sequence":"additional","affiliation":[{"name":"University of South Alabama","place":["United States"]},{"name":"Federal University of Jatai","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler","family":"Beling","sequence":"additional","affiliation":[{"name":"University of South Alabama","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1835-2317","authenticated-orcid":false,"given":"Shubhnita","family":"Singh","sequence":"additional","affiliation":[{"name":"University of Pennsylvania School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliano V.","family":"Alves","sequence":"additional","affiliation":[{"name":"University of Sao Paulo","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8925-9929","authenticated-orcid":false,"given":"Wanessa M. C.","family":"Awata","sequence":"additional","affiliation":[{"name":"University of Sao Paulo","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0157-2478","authenticated-orcid":false,"given":"Angela","family":"Russ","sequence":"additional","affiliation":[{"name":"University of South Alabama","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8577-1454","authenticated-orcid":false,"given":"Adeyeye Isaac","family":"Haastrup","sequence":"additional","affiliation":[{"name":"University of South Alabama","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3571-5845","authenticated-orcid":false,"given":"Rolando A.","family":"Cuevas","sequence":"additional","affiliation":[{"name":", University of Pittsburgh","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3807-1109","authenticated-orcid":false,"given":"Parya","family":"Behzadi","sequence":"additional","affiliation":[{"name":", University of Pittsburgh","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1871-6915","authenticated-orcid":false,"given":"Cynthia","family":"St. Hilaire","sequence":"additional","affiliation":[{"name":", University of Pittsburgh","place":["United States"]},{"name":"University of Pittsburgh","place":["United States"]},{"name":"University of Pittsburgh","place":["United States"]},{"name":"University of Pittsburgh","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4433-1234","authenticated-orcid":false,"given":"Justin T.","family":"Roberts","sequence":"additional","affiliation":[{"name":"University of South Alabama","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7067-4048","authenticated-orcid":false,"given":"Ariane","family":"Bruder","sequence":"additional","affiliation":[{"name":"University of South Alabama","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5671-318X","authenticated-orcid":false,"given":"Thiago","family":"Bruder-Nascimento","sequence":"additional","affiliation":[{"name":"University of South Alabama","place":["United States"]},{"name":", University of South Alabama","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacasi.2024.02.002"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.11.005"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000177474.06749.98"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-022-00739-0"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-022-00906-w"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgg.2014.08.001"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.125.045304"},{"key":"B8","doi-asserted-by":"publisher","unstructured":"Pernomian L, Waigi EW, Nguyen V, Mohammed AD, da Costa TJ, Fontes MT, Kubinak JL, Aitken A, Biancardi VC, Sinclair DA, McCarthy CG, Wang Y, Tan W, Wenceslau CF. A single-short partial reprogramming of the endothelial cells decreases blood pressure via attenuation of EndMT in hypertensive mice (Preprint). bioRxiv, 2024. doi:10.1101\/2024.05.20.595057. 38826452","DOI":"10.1101\/2024.05.20.595057"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0812429"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2019.154796"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-02973-0"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-022-01124-3"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.02.017"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.030353"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.124.037640"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2017.03.020"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2005.04.006"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2016.05.003"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2019.12.009"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.173863"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1111\/acel.70500"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3791\/62439"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.123.21888"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00365.2023"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2015666118"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abb0203"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.18632\/aging.206175"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2023.10.006"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01211-8"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12287"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01251-0"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00646-9"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13557"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/126240"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.14670\/HH-18-076"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1994-2"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1096\/fba.2023-00084"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2023.133199"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12525"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203579"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2024.106744"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2020.1845332"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-024-01817-1"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00012.2026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T15:06:48Z","timestamp":1782400008000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00012.2026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,7,1]]}},"alternative-id":["10.1152\/ajpheart.00012.2026"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00012.2026","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,1]]},"assertion":[{"value":"2026-01-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-26","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}