{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T10:41:41Z","timestamp":1779014501907,"version":"3.51.4"},"reference-count":78,"publisher":"American Physiological Society","issue":"6","funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["16POST31080031"],"award-info":[{"award-number":["16POST31080031"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["19CDA34660318"],"award-info":[{"award-number":["19CDA34660318"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["P01HL06999"],"award-info":[{"award-number":["P01HL06999"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2020,6,1]]},"abstract":"<jats:p> With a longitudinal cohort, novel observations from the present study demonstrate that individuals who had lower Sirt1 early in life exhibit premature microvascular dysfunction during adulthood and may be at higher risk to develop CVD. These results provide experimental evidence that Sirt1 may play an important role in microvascular function with age and represent a potential therapeutic target to prevent premature vascular dysfunction. <\/jats:p>","DOI":"10.1152\/ajpheart.00024.2020","type":"journal-article","created":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T19:32:37Z","timestamp":1587756757000},"page":"H1371-H1378","source":"Crossref","is-referenced-by-count":22,"title":["Sirt1 during childhood is associated with microvascular function later in life"],"prefix":"10.1152","volume":"318","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3582-4483","authenticated-orcid":false,"given":"Paula","family":"Rodriguez-Miguelez","sequence":"first","affiliation":[{"name":"Department of Kinesiology and Health Sciences, Virginia Commonwealth University, Richmond, Virginia"},{"name":"Georgia Prevention Institute, Augusta University, Augusta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Looney","sequence":"additional","affiliation":[{"name":"Georgia Prevention Institute, Augusta University, Augusta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Thomas","sequence":"additional","affiliation":[{"name":"Georgia Prevention Institute, Augusta University, Augusta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Harshfield","sequence":"additional","affiliation":[{"name":"Georgia Prevention Institute, Augusta University, Augusta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer S.","family":"Pollock","sequence":"additional","affiliation":[{"name":"Georgia Prevention Institute, Augusta University, Augusta, Georgia"},{"name":"Cardio-Renal Physiology and Medicine, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan A.","family":"Harris","sequence":"additional","affiliation":[{"name":"Georgia Prevention Institute, Augusta University, Augusta, Georgia"},{"name":"Sport and Exercise Science Research Institute, University of Ulster, Jordanstown, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37027-2"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq339"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00544.2011"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.308895"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1003833107"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1177\/001316447303300111"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9391261"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-015-0357-9"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2010.117"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1111\/micc.12257"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2017.7178"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/653239"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.211219"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.303735"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-4252"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001604"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1186\/1478-811X-12-23"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-017-9685-9"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000112379.88385.67"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.150821"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-017-2595-9"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2018-0083"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00858.2007"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3233\/BIR-130645"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.15436\/2378-6841.19.2039"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.34.5.1026"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00589.2017"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1042\/CS20070431"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001511"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061560"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12260"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2013.00863"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2019.03.011"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-56635-0"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2019.1638694"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq431"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/171383"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.07.002"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.10.058"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00449"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-014-0465-x"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-015-1859-4"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.004400"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0704329104"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2019.04.024"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1080\/10739680802091526"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12151"},{"key":"B48","first-page":"1015","volume":"64","author":"Merk HF","year":"1989","journal-title":"Z Hautkr"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/nature06261"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00414.2010"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00587.2011"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1998.00718.x"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.210500"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.300536"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2011.11.010"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2011.11.014"},{"key":"B57","first-page":"14","volume":"17","author":"Rasool AH","year":"2010","journal-title":"Malays J Med Sci"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq165"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.2003.01179.x"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.3791\/54011"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1111\/j.1549-8719.2011.00129.x"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-019-0459-9"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.07.013"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00468.x"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.4161\/cc.10.4.14863"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12396925"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-02-484956"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199801150-00020"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv290"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2008.02609.x"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0193921"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2017.05.004"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-011-0825-4"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2016.02.003"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn224"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-015-0472-7"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2014.10.016"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.215483"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00024.2020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T12:59:34Z","timestamp":1589201974000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00024.2020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,1]]},"references-count":78,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6,1]]}},"alternative-id":["10.1152\/ajpheart.00024.2020"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00024.2020","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,1]]}}}